Principles of Molecular Regulation

1. Front Matter

   Pages i-xiv

   PDF

2. Signaling Mechanisms Initiated by Cell Surface Receptors

   1. Front Matter

      Pages 1-1

      PDF

   2. G Protein-Coupled Receptors and G Proteins

      • Alfredo Ulloa-Aguirre, P. Michael Conn

      Pages 3-25

   3. G Proteins Large and Small Guanine Nucleotide Binding Proteins

      • Thomas M. Wilkie, Michael A. White

      Pages 27-39

   4. The Insulin Receptor Kinase

      • Barry I. Posner

      Pages 41-53

   5. Growth Hormone Action

      • David J. Waxman, Stuart J. Frank

      Pages 55-83

   6. Regulation of Drosophila Visual Transduction Through a Supramolecular Signaling Complex

      • Craig Montell

      Pages 85-97

   7. Dictyostelium

      • Chang Y. Chung, Richard A. Firtel

      Pages 99-114

   8. gp130-Related Cytokines

      • Christoph J. Auernhammer, Shlomo Melmed

      Pages 115-132

3. Signaling Mechanisms Mediated by Ion Channels, Calcium, and Lipids

   1. Front Matter

      Pages 133-133

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   2. Ion Channels

      • Deborah J. Nelson, Harry A. Fozzard

      Pages 135-148

   3. Calcium Ions as Intracellular Messengers

      • Stanko S. Stojilkovic, Melanija Tomić, Taka-aki Koshimizu, Fredrick Van Goor

      Pages 149-185

   4. Calcium and Calmodulin-Mediated Regulatory Mechanisms

      • Anthony R. Means

      Pages 187-204

   5. Protein Kinase C

      • Alexandra C. Newton

      Pages 205-218

   6. Nitric Oxide

      • Randy Krainock, Sean Murphy

      Pages 219-227

   7. Phospholipases

      • J. H. Exton

      Pages 229-245

4. Cyclic AMP, Protein Kinases and Protein Phosphatases

   1. Front Matter

      Pages 247-247

      PDF

   2. Adenylyl Cyclases

      • Lutz Birnbaumer

      Pages 249-260

   3. Cyclic Nucleotide Phosphodiesterases

      • Marco Conti

      Pages 261-275

   4. Cyclic Nucleotide-Dependent Protein Kinases

      • Sharron H. Francis, Jackie D. Corbin

      Pages 277-296

With the dramatic growth in our knowledge of hormone action and the mechanisms of cell regulation, the need for an up-to-date broad-ranging survey of these processes has become pressing. In Principles of Molecular Regulation, P. Michael Conn and Anthony Means have successfully assembled a panel of leading investigators to provide an integrated review of the key areas-membrane receptor-initiated cell signaling and nuclear receptor-initiated gene regulation. Chosen for the excellence of their research as well as their demonstrated writing skills, these distinguished authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their comprehensive review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases. They also discuss the molecular regulation of cell proliferation and death, as well as the impact of new technologies on rational drug discovery. Capturing the excitement now present at this vibrant union of molecular biology, cell biology, and endocrinology, Principles of Molecular Regulation constitutes a major new resource for understanding the many and complex elements of biological regulation. Its up-to-date critical synthesis is certain to prove of high value to all basic and clinical investigators working with these processes today.

• G protein-coupled receptors
• G proteins
• cell biology
• cell surface receptors
• hormone receptors
• insulin
• nuclear receptors
• regulation

"In this volume of Principles of Molecular Regulation, one has the opportunity to survey the state of membrane receptor initiated cell signaling and nuclear receptor initiated gene regulation from viewpoints of a selected cadre of leading investigators. . .the reader can savor the current progress and excitement in this vibrant field of molecular endocrinology." -Bert W. O'Malley

"...has made a brave attempt to give the reader a bird's eye-view on all the possible molecular signals that cells receive, all the different mechanisms to which cells respond and the errors made by cells during signaling that could lead to disease or death. The book, enriched with diagrams of the concepts discussed, is divided into six parts, and should be an excellent source of facts and reference for teachers, researchers and physicians working in many different areas of biology and medicine...The organization of the six different themes makes this a good textbook for course on signal transduction at the senior undergraduate or graduate level...this book is a valuable addition to the field of signal transduction and the authors and editors must be applauded for a job well done." - TRENDS in Endocrinology & Metabolism

"...the volume provides background and breadth absent from typical reviews. It could serve as an excellent textbook for a graduate-level course and will be a valuable resource for investigators interested in cell signaling."- Patricia M. Hinkle

"This book constitutes a new resource for understanding the many and complex elements of biological regulation. In this volume, the authors have assembled a panel of leading investigators to provide an integrated review of the key areas." - Lavoisier Librairie

"For the established cell biologist, this book will provide some useful insights especially in fields just off the readers' regular patch." -Cell Biology International

"A clearly written, richly illustrated, amply referenced volume describing the latest on the regulation of hormone action. A highly recommended book, not only to endocrine researchers and teachers but to all curious endocrinologists who want, beyond practice, to understand the basic science of endocrinology." -Journal of Pediatric Endocrinology and Metabolism

"...presents state-of-the-art technology for DNA analysis...it offers a comprehensive and modern guide to the fast, reliable, and powerful technologies for the analysis of DNA variation. We are looking forward to having the second volume of the series." -Die Pharmazie

"This book describes extensively some of the fundamental aspects of living organisms such as membrane receptor initiated cell signaling, nuclear receptor initiated gene regulation or molecular regulation of cell proliferation ... Throughout the text is supplemented with several comprehensive tables and figures. It is therefore intended not only for research workers familiar with some aspects of regulation, but also to students wanting to learn more about basic concepts of signaling mechanisms. In conclusion, this book surveys the current state and perspectives of cell signaling and gene regulation, and should be recommended to all those interested in the process of life and its mechanisms of regulation at the molecular level." - Biochimie

• Oregon Regional Primate Research Center, Beaverton, and Oregon Health Sciences University, Portland, USA

  P. Michael Conn

• Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, USA

  Anthony R. Means

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