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5-HT2C Receptors in the Pathophysiology of CNS Disease

  • Book
  • © 2011

Overview

  • Examines 5-HT2C receptor subclass as a possible therapeutic target for the development of drugs for a range of CNS disorders such as schizophrenia, depression, drug abuse, eating disorders, Parkinson’s disease and epilepsy
  • Updates the functional status of the 5-HT2C receptor
  • Written by an international group of accomplished leaders in this field
  • Includes supplementary material: sn.pub/extras

Part of the book series: The Receptors (REC, volume 22)

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Table of contents (26 chapters)

About this book

Part of Springer’s “The Receptors,” series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors’ therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson’s disease, Prader-Willi Syndrome, Alzheimer’s disease and epilepsy.

Reviews

From the reviews:

“The book is well presented with good use of diagrams … . There is a good mix of international authors with acknowledged leaders in the field being responsible for some key chapters. … In summary this is a useful book describing the properties of a receptor that may well turn out to be a therapeutically important drug target with selective ligands already being evaluated in phase II trials for control of appetite.” (R. G. Hill, British Journal of Clinical Pharmacology, May, 2011)

Editors and Affiliations

  • , Department of Physiology and Biochemistr, University of Malta, Malta, Italy

    Giuseppe Di Giovanni

  • Centro di Ricerche Farmacologiche e, Biomediche, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy

    Ennio Esposito, Vincenzo Di Matteo

Bibliographic Information

  • Book Title: 5-HT2C Receptors in the Pathophysiology of CNS Disease

  • Editors: Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1007/978-1-60761-941-3

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-60761-940-6Published: 01 December 2010

  • Softcover ISBN: 978-1-61779-720-0Published: 28 January 2013

  • eBook ISBN: 978-1-60761-941-3Published: 30 November 2010

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: XII, 560

  • Topics: Neurosciences, Pharmacology/Toxicology, Human Physiology, Neurobiology, Neurology

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