The Receptors

5-HT2C Receptors in the Pathophysiology of CNS Disease

Editors: Di Giovanni, Giuseppe, Esposito, Ennio, Di Matteo, Vincenzo (Eds.)

  • 1. Examines 5-HT2C receptor subclass as a possible therapeutic target for the development of drugs for a range of CNS disorders such as schizophrenia, depression, drug abuse, eating disorders, Parkinson’s disease and epilepsy
  • 2. Updates the functional status of the 5-HT2C receptor
  • 3. Written by an international group of accomplished leaders in this field
see more benefits

Buy this book

eBook $269.00
price for USA (gross)
  • ISBN 978-1-60761-941-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $339.00
price for USA
  • ISBN 978-1-60761-940-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $339.00
price for USA
  • ISBN 978-1-61779-720-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Research of 5-HT2c receptors stretches back twenty-five years, and while much of it has been productive, the past decade of research has been extraordinary in terms of both amount produced and insights gained. It is hardly surprising that 5-HT2c receptor research has grown so fruitful, given that it is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a major role in the regulation of numerous behaviors. It has further been shown by experimental and clinical observation that it may represent a possible therapeutic target for the development of drugs for a range of central nervous system disorders. The time, therefore, is more than appropriate to offer the first ever overview of the research of 5-HT2c receptors. Part of the popular and important series, “The Receptors,” The 5-HT2c Receptor provides a thorough update of the functional status of the 5-HT2c receptor. It covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor so as to highlight its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. In addition, the book investigates the receptors’ therapeutic potential in a range of different diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson’s disease, Prader-Willi Syndrome, Alzheimer’s disease and epilepsy. While not exhaustive, this text is a vital tool in understanding the past and inspiring the future of interdisciplinary research on the 5-HT2c receptor.

Reviews

From the reviews:

“The book is well presented with good use of diagrams … . There is a good mix of international authors with acknowledged leaders in the field being responsible for some key chapters. … In summary this is a useful book describing the properties of a receptor that may well turn out to be a therapeutically important drug target with selective ligands already being evaluated in phase II trials for control of appetite.” (R. G. Hill, British Journal of Clinical Pharmacology, May, 2011)

Table of contents (26 chapters)

  • The Making of the 5-HT2C Receptor

    Palacios, Jose M. (et al.)

    Pages 1-16

  • Serotonin 5-HT2C Receptors: Chemical Neuronatomy in the Mammalian Brain

    Mengod, Guadalupe

    Pages 17-27

  • The Medicinal Chemistry of 5-HT2C Receptor Ligands

    Leopoldo, Marcello (et al.)

    Pages 29-50

  • Insights into 5-HT2C Receptor Function Gained from Transgenic Mouse Models

    Bonasera, Stephen J.

    Pages 51-73

  • Serotonin 5-HT2C Receptor Signal Transduction

    Garnovskaya, Maria N. (et al.)

    Pages 75-96

Buy this book

eBook $269.00
price for USA (gross)
  • ISBN 978-1-60761-941-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $339.00
price for USA
  • ISBN 978-1-60761-940-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $339.00
price for USA
  • ISBN 978-1-61779-720-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
5-HT2C Receptors in the Pathophysiology of CNS Disease
Editors
  • Giuseppe Di Giovanni
  • Ennio Esposito
  • Vincenzo Di Matteo
Series Title
The Receptors
Series Volume
22
Copyright
2011
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-60761-941-3
DOI
10.1007/978-1-60761-941-3
Hardcover ISBN
978-1-60761-940-6
Softcover ISBN
978-1-61779-720-0
Edition Number
1
Number of Pages
XII, 560
Topics