Oxidative Stress in Applied Basic Research and Clinical Practice

Studies on Renal Disorders

Editors: Miyata, Toshio, Eckardt, Kai-Uwe, Nangaku, Masaomi (Eds.)

  • Covers broad derangements of oxygen metabolism, such as oxidative stress and hypoxia
  • Covers the defensive mechanisms against oxidative stress (e.g. the Nrf2-Keap1 system) and hypoxia (e.g. the PHD-HIF system)
  • Leading basic researchers and clinical scientists provide up-to-date, cutting-edge reviews on recent advances in the pathobiology of oxygen metabolism in kidney disease, especially oxidative stress and hypoxia
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eBook $339.00
price for USA (gross)
  • ISBN 978-1-60761-857-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $429.00
price for USA
  • ISBN 978-1-60761-856-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Conditions such as oxidative stress and hypoxia, which have a generalized impact on the oxygen metabolism, have been implicated in the genesis of kidney disease. This means that deepening our understanding of the pathobiology of oxygen metabolism in such diseases could be a fruitful path towards tangible clinical benefits. Studies in Renal Disorder collects reviews from leading researchers and clinical scientists working in exactly this field, providing an overview of the latest advances. The causal role of impaired oxygen metabolism in kidney disease has numerous clinical implications. It affects our understanding of the therapeutic benefits accruing from anti-hypertensive agents; the way we control hyperglycemia/hyperinsulinemia and hyperlipidemia; and our use of dietary approaches to the correction of obesity. The defensive mechanisms against oxidative stress, such as the Nrf2-Keap1 system, and hypoxia, such as the PHD-HIF system, have recently been explored in various cells, including kidney cells. These mechanisms include intracellular sensors for oxidative stress and hypoxia. This means that novel approaches targeting these sensors may offer clinical benefits in kidney disease in which oxidative stress and/or hypoxia is a final, common pathway.

Reviews

From the reviews:

“This book is a collection of reviews on derangements of oxygen metabolism in kidney diseases. … addressed to students (mostly postgraduate), researchers, and academic clinicians … . I liked the organization of each chapter with an abstract, key words, introduction, and conclusion as well as extensive, up-to-date, relevant references. … This is the only book that I am aware of that is an extensive, updated review of abnormal oxygen metabolism in a large number of pathologic renal diseases.” (Mony Fraer, Doody’s Review Service, July, 2011)

Table of contents (34 chapters)

  • Oxidative Stress Injury in Glomerular Mesangium

    Pfeilschifter, Josef (et al.)

    Pages 3-23

  • Transition Metals and Other Forms of Oxidative Protein Damage in Renal Disease

    Monnier, Vincent M. (et al.)

    Pages 25-50

  • Cyclooxygenase in the Kidney and Oxidative Stress

    Harris, Raymond C.

    Pages 51-69

  • Renin-Angiotensin System in the Kidney and Oxidative Stress: Local Renin-Angiotensin-Aldosterone System and NADPH Oxidase-Dependent Oxidative Stress in the Kidney

    Kiyomoto, Hideyasu (et al.)

    Pages 71-91

  • Thiamine in Diabetic Renal Disease: Dietary Insufficiency, Renal Washout, Antistress Gene Response, Therapeutic Supplements, Risk Predictor, and Link to Genetic Susceptibility

    Thornalley, Paul J. (et al.)

    Pages 93-104

Buy this book

eBook $339.00
price for USA (gross)
  • ISBN 978-1-60761-857-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $429.00
price for USA
  • ISBN 978-1-60761-856-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Studies on Renal Disorders
Editors
  • Toshio Miyata
  • Kai-Uwe Eckardt
  • Masaomi Nangaku
Series Title
Oxidative Stress in Applied Basic Research and Clinical Practice
Copyright
2011
Publisher
Humana Press
Copyright Holder
Springer Science + Business Media, LLC
eBook ISBN
978-1-60761-857-7
DOI
10.1007/978-1-60761-857-7
Hardcover ISBN
978-1-60761-856-0
Series ISSN
2197-7224
Edition Number
1
Number of Pages
XVIII, 786
Topics