Methods in Molecular Biology

Alzheimer's Disease and Frontotemporal Dementia

Methods and Protocols

Editors: Roberson, Erik D. (Ed.)

  • -Supplies easily accessible techniques for the complex and wide-ranging avenues of AD and FTD research -Features invaluable descriptions of the experience of experts in the field to aid in the successful completion of experiments -Examines the diversity of the field today in a practical, lab-ready manner

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eBook $109.00
price for USA (gross)
  • ISBN 978-1-60761-744-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-60761-743-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Alzheimer’s disease and frontotemporal dementia, two of the most prevalent neurodegenerative diseases, are dreaded disorders that attack the neural networks underlying memory and personality, systems that make us who we are. Major breakthroughs in recent years have spurred new research approaches to these conditions. In Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols, expert investigators bring together the many divergent areas of expertise used to study these diseases, including behavior, electrophysiology, confocal microscopy, and hardcore biochemistry. Beginning with an overview of the two diseases and contemporary research on them, the book continues with specialized protocols for working with amyloid-β peptide, tau, and apolipoprotein E as well as experimental systems for studying AD and FTD, including cell and animal models, and outcome measures that can be used to assess neuronal function in these systems. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols serves as an ideal guide for all scientists pursuing the cause and cure of these widespread and nightmarishly debilitating disorders.

Reviews

From the reviews:

“This book brings together research authorities in the field of Alzheimer’s disease (AD) and frontotemporal dementia (FTD) to share their laboratory methods and protocols for molecular and model systems and outcome research in the field of neurodegenerative biomedical research. … The audience includes all laboratory scientists interested in molecular and neuroscience research that seeks a cause and cure for these two devastating disorders. … The book is thoughtfully written and will have the greatest appeal for those with a familiarity with laboratory research methods.” (Charlene Hoffman Snyder, Doody’s Review Service, February, 2011)

“This is a collection of relatively modern methodologies, focused primarily on the study of amyloid-β processing … . Research technicians will find the ‘notes’ sections particularly valuable … . provides a nice reference for anyone interested in studying putative models of Alzheimer’s disease. … Overall, the book is well organized, well written, appropriately succinct, and exceedingly useful in those areas that are addressed, and provides a valuable reference to the basic scientist studying Alzheimer’s disease.” (Rudy J. Castellani, Journal of Alzheimer’s Disease, Vol. 25, 2011)


Table of contents (18 chapters)

  • Contemporary Approaches to Alzheimer’s Disease and Frontotemporal Dementia

    Roberson, Erik D.

    Pages 1-9

  • Preparing Synthetic Aβ in Different Aggregation States

    Stine, W. Blaine (et al.)

    Pages 13-32

  • Isolation of Low-n Amyloid β-Protein Oligomers from Cultured Cells, CSF, and Brain

    Shankar, Ganesh M. (et al.)

    Pages 33-44

  • Detecting Aβ*56 Oligomers in Brain Tissues

    Sherman, Mathew A. (et al.)

    Pages 45-56

  • Assessing Aβ Aggregation State by Atomic Force Microscopy

    Legleiter, Justin

    Pages 57-70

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-60761-744-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-60761-743-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Alzheimer's Disease and Frontotemporal Dementia
Book Subtitle
Methods and Protocols
Editors
  • Erik D. Roberson
Series Title
Methods in Molecular Biology
Series Volume
670
Copyright
2011
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-60761-744-0
DOI
10.1007/978-1-60761-744-0
Hardcover ISBN
978-1-60761-743-3
Series ISSN
1064-3745
Edition Number
1
Number of Pages
X, 277
Topics