Oxidative Stress in Applied Basic Research and Clinical Practice

Aging and Age-Related Disorders

Editors: Bondy, Stephen, Maiese, Kenneth (Eds.)

  • Features the knowledge of internationally recognized experts
  • Provides chapters that examine the interactive relationship between systems in the body, such as the nervous system and vascular system, that can enhance or sometimes even limit cellular longevity Highlights emerging knowledge and therapy for the understanding of the basis and development of aging – related disorders
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eBook $229.00
price for USA (gross)
  • ISBN 978-1-60761-602-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-60761-601-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61779-699-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.

Table of contents (22 chapters)

  • Protein Redox-Regulation Mechanisms in Aging

    Çakatay, Ufuk

    Pages 3-25

  • Nitrosative Stress in Aging – Its Importance and Biological Implications in NF-κB Signaling

    Ljubuncic, Predrag (et al.)

    Pages 27-54

  • Intervention with Multiple Micronutrients Including Dietary and Endogenous Antioxidants for Healthy Aging

    Prasad, Kedar N.

    Pages 55-78

  • Advanced Glycation End Products, RAGE, and Aging

    Ramasamy, Ravichandran (et al.)

    Pages 79-90

  • Sirtuins and Mammalian Aging

    Sharman, Edward H.

    Pages 91-117

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-60761-602-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-60761-601-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61779-699-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Aging and Age-Related Disorders
Editors
  • Stephen Bondy
  • Kenneth Maiese
Series Title
Oxidative Stress in Applied Basic Research and Clinical Practice
Copyright
2010
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-60761-602-3
DOI
10.1007/978-1-60761-602-3
Hardcover ISBN
978-1-60761-601-6
Softcover ISBN
978-1-61779-699-9
Series ISSN
2197-7224
Edition Number
1
Number of Pages
XVI, 472
Topics