Aging and Age-Related Disorders

1. Front Matter

   Pages i-xv

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2. General Aspects of Aging

   1. Front Matter

      Pages 1-1

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   2. Protein Redox-Regulation Mechanisms in Aging

      • Ufuk Çakatay

      Pages 3-25

   3. Nitrosative Stress in Aging – Its Importance and Biological Implications in NF-κB Signaling

      • Predrag Ljubuncic, Einat Gochman, Abraham Z. Reznick

      Pages 27-54

   4. Intervention with Multiple Micronutrients Including Dietary and Endogenous Antioxidants for Healthy Aging

      • Kedar N. Prasad

      Pages 55-78

   5. Advanced Glycation End Products, RAGE, and Aging

      • Ravichandran Ramasamy, Loredana G. Bucciarelli, Shi Fang Yan, Ann Marie Schmidt

      Pages 79-90

   6. Sirtuins and Mammalian Aging

      • Edward H. Sharman

      Pages 91-117

   7. Estrogenic Modulation of Longevity by Induction of Antioxidant Enzymes

      • Jose Viña, Consuelo Borrás, Mari Carmen Gómez-Cabrera, Juan Gambini, Raul López-Grueso, Federico V. Pallardó

      Pages 119-128

   8. Mitochondrial Respiratory Function Decline in Aging and Life-Span Extension by Caloric Restriction

      • Shi-Bei Wu, Yu-Ting Wu, Chih-Hao Wang, Wan-Yu Lee, Yau-Huei Wei

      Pages 129-148

   9. Methylglyoxal, Oxidative Stress, and Aging

      • Miklós Péter Kalapos, Kaushik M. Desai, Lingyun Wu

      Pages 149-167

3. The Cardiovascular System

   1. Front Matter

      Pages 169-169

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   2. Novel Strategies for Neurovascular Longevity During Aging

      • Kenneth Maiese, Zhao Zhong Chong, Jinling Hou, Yan Chen Shang

      Pages 170-208

   3. Oxidative Stress in Vascular Disease

      • Isabelle Gorenne, Martin R. Bennett

      Pages 211-235

   4. The Role of Mitochondrial Reactive Oxygen Species Formation for Age-Induced Vascular Dysfunction

      • Andreas Daiber, Joachim Kienhoefer, Rebecca Zee, Philip Wenzel, Volker Ullrich, Bernd Loo et al.

      Pages 237-257

   5. Aging, Oxidative Stress, and Cardiovascular Disorders

      • Yi Shi, Giovanni G. Camici, Thomas F. Lüscher

      Pages 259-275

   6. Oxidative Stress, Aging, and Cardiovascular Disease

      • G. Riccioni, V. Sblendorio, N. D’Orazio

      Pages 277-296

   7. Antioxidation in Prevention of Cardiovascular Diseases – An Effect of Polyphenols

      • Jun-ichi Suzuki, Mitsuaki Isobe, Ryuichi Morishita, Ryozo Nagai

      Pages 297-307

   8. Vascular Aging and Oxidative Stress: Hormesis and Adaptive Cellular Pathways

      • Nathalie Thorin-Trescases, Eric Thorin

      Pages 309-321

   9. Role of Oxidative Stress in Mediating Elevated Blood Pressure with Aging

      • Julio Sartori Valinotti, Licy Yanes, Jane F. Reckelhoff

      Pages 323-336

4. The Nervous System

   1. Front Matter

      Pages 337-337

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Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.

• Aging, Oxidative Stress, Neurology
• Alzheimer
• Regulation
• age
• cells
• development
• influence

• Center for Occupational & Environmental, Department of Medicine, University of California, Irvine, Irvine, USA

  Stephen Bondy

• New Jersey Medical School, Department of Neurology and Neuroscience, University of Medicine & Dentistry of Ne, Newark, USA

  Kenneth Maiese

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