Current Cancer Research

Protein Kinase C in Cancer Signaling and Therapy

Editors: Kazanietz, Marcelo G. (Ed.)

  • Focuses specifically on PKC signaling at a mechanistic level in the context of cancer
  • The first to present, in a very detailed manner, the implication of PKC isozymes in different types of cancers
  • There will be a full section on anticancer agents that target PKC and on how PKC modulates the sensitivity of cancer cells to chemotherapeutic drugs
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eBook $269.00
price for USA (gross)
  • ISBN 978-1-60761-543-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $339.00
price for USA
  • ISBN 978-1-60761-542-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $339.00
price for USA
  • ISBN 978-1-61779-691-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor-promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents.

Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. It is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable.

Protein Kinase C in Cancer Signaling and Therapy is composed of twenty-three chapters written by leading experts in the field. The book is divided into four sections: Regulation of PKC isozyme function: from genes to biochemistry, PKC isozymes in the control of cell function, PKC isozymes in cancer, and PKC isozymes as targets for cancer therapy. Each section of Protein Kinase C in Cancer Signaling and Therapy begins with an introduction by an established professional in the field of Protein kinase C, followed by chapters that elucidate the importance of PKC in current cancer research.

Table of contents (23 chapters)

  • Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective

    Toker, Alex

    Pages 3-8

  • Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids

    Newton, Alexandra C.

    Pages 9-23

  • Phorbol Esters and Diacylglycerol: The PKC Activators

    Blumberg, Peter M. (et al.)

    Pages 25-53

  • Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals

    Mérida, Isabel (et al.)

    Pages 55-78

  • Regulation of PKC by Protein–Protein Interactions in Cancer

    Kim, Jeewon (et al.)

    Pages 79-103

Buy this book

eBook $269.00
price for USA (gross)
  • ISBN 978-1-60761-543-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $339.00
price for USA
  • ISBN 978-1-60761-542-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $339.00
price for USA
  • ISBN 978-1-61779-691-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Protein Kinase C in Cancer Signaling and Therapy
Editors
  • Marcelo G. Kazanietz
Series Title
Current Cancer Research
Copyright
2010
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-60761-543-9
DOI
10.1007/978-1-60761-543-9
Hardcover ISBN
978-1-60761-542-2
Softcover ISBN
978-1-61779-691-3
Series ISSN
2199-2584
Edition Number
1
Number of Pages
XIV, 494
Number of Illustrations and Tables
26 b/w illustrations, 11 illustrations in colour
Topics