Molecular and Translational Medicine

Targeted Therapies

Mechanisms of Resistance

Editors: Gioeli, Daniel (Ed.)

  • For the physician-scientist treating patients
  • Describes advantages and pitfalls of experimental models currently in use
  • Leading edge techniques
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About this book

This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. 

Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

Reviews

From the reviews:

“This is an important resource, providing a mechanistic understanding of the signaling event in cancer for developing effective targeted cancer therapies, as well as computational biology and systems theory. … great value to oncologists and physician-scientists treating patients, and translational scientists … . even students interested in this field will find it useful. … an important book for understanding major mechanisms of resistance to targeted cancer therapeutic agents as well as microRNA as a potential therapy capable of targeting multiple cancer signaling pathways.” (Omer Iqbal, Doody’s Review Service, September, 2011)

“The book provides a well-balanced insight into the topic of drug resistance … . the reader can find a lot of information about the progress and inspiration how to overcome the cancer resistance. The book represents a useful source of knowledge for cell and molecular biologists, geneticists, professionals in bioinformatics, researchers and physicians working in translational oncology.” (J. Sedlak, Neoplasma, Issue 6, November-December, 2012)


Table of contents (10 chapters)

  • Resistance to Targeted Therapies As a Result of Mutation(s) in the Target

    Cortot, Alexis B. (et al.)

    Pages 1-31

  • The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies

    Gioeli, Daniel

    Pages 33-53

  • Cancer Signaling Network Analysis by Quantitative Mass Spectrometry

    Neil, Jason R. (et al.)

    Pages 55-75

  • Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications

    Wulfkuhle, Julia D. (et al.)

    Pages 77-94

  • Using Phosphoflow™ to Study Signaling Events of Subpopulations Resistant to Current Therapies

    Perez, Omar D.

    Pages 95-112

Buy this book

eBook $179.00
price for USA (gross)
  • ISBN 978-1-60761-478-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-1-60761-477-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $229.00
price for USA
  • ISBN 978-1-61779-744-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Targeted Therapies
Book Subtitle
Mechanisms of Resistance
Editors
  • Daniel Gioeli
Series Title
Molecular and Translational Medicine
Copyright
2011
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-60761-478-4
DOI
10.1007/978-1-60761-478-4
Hardcover ISBN
978-1-60761-477-7
Softcover ISBN
978-1-61779-744-6
Series ISSN
2197-7852
Edition Number
1
Number of Pages
XIV, 202
Topics