Methods in Molecular Biology

Multi-Drug Resistance in Cancer

Editors: Zhou, Jun (Ed.)

  • Collects comprehensive reviews written by leading scientists in the field
  • Provides up-to-date techniques for detection and imaging of drug transporters
  • Offers strategies to evaluate the efficacy of resistance reversal agents
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eBook $149.00
price for USA (gross)
  • ISBN 978-1-60761-416-6
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  • Included format: EPUB, PDF
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  • Immediate eBook download after purchase
Hardcover $189.00
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  • ISBN 978-1-60761-415-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
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  • ISBN 978-1-61779-664-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

With the devastating complication of cancer cells becoming simultaneously resistant to many structurally and mechanistically unrelated drugs, the efficacy of chemotherapeutic management of cancer often becomes severely limited. In Multi-Drug Resistance in Cancer, leading researchers in the field provide comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance protein, to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The extensive volume also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression, as well as techniques for detection and imaging of drug transporters, methods for investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.

Authoritative and cutting-edge, Multi-Drug Resistance in Cancer offers a state-of-art collection of reviews and methods for both basic and clinician investigators who are interested in the vital study of cancer multi-drug resistance mechanisms and reversal strategies.

Reviews

From the reviews:

“This book uses cancer as the focus to discuss both the mechanistic events causing multi-drug resistance and the potential ways to mitigate it. … In summary, this book provides a good overview of the development and treatment of multi-drug resistance in cancer. … each individual chapter covers a specific area in an easy-to-read manner, which should leave the reader with a better understanding of the topic.” (Nick Plant, BTS Newsletter, Issue 37, Winter, 2010)

“The topics covered in this 21-chapter volume have been provided by leading experts in the field. … The chapters are generally well written and clear. … This provides a full picture on what is going on in this exciting field. … this book offers a comprehensive survey of the fields of knowledge and research concerning cancer multi-drug resistance mechanisms and reversal strategies. In this way, it is relevant for basic and clinical investigators, for the less experienced and mature researchers … .” (Rolf W. Hartmann, ChemMedChem, Vol. 6 (3), 2011)


Table of contents (21 chapters)

  • Multidrug Resistance in Cancer

    Baguley, Bruce C.

    Pages 1-14

  • Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets

    Nagengast, Wouter B. (et al.)

    Pages 15-31

  • Studying Drug Resistance Using Genetically Engineered Mouse Models for Breast Cancer

    Rottenberg, Sven (et al.)

    Pages 33-45

  • Mechanisms of Multidrug Resistance in Cancer

    Gillet, Jean-Pierre (et al.)

    Pages 47-76

  • Molecular Mechanisms of Drug Resistance in Single-Step and Multi-Step Drug-Selected Cancer Cells

    Calcagno, Anna Maria (et al.)

    Pages 77-93

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-60761-416-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-60761-415-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-61779-664-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Multi-Drug Resistance in Cancer
Editors
  • Jun Zhou
Series Title
Methods in Molecular Biology
Series Volume
596
Copyright
2010
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60761-416-6
DOI
10.1007/978-1-60761-416-6
Hardcover ISBN
978-1-60761-415-9
Softcover ISBN
978-1-61779-664-7
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XII, 492
Number of Illustrations and Tables
63 b/w illustrations, 4 illustrations in colour
Topics