Immunotoxicity Testing

Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory protocols, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls.

Comprehensive and innovative, Immunotoxicity Testing: Methods and Protocols is a critical, one-stop reference resource for the most important and commonly used laboratory protocols in immunotoxicology.

• Alternative approaches
• Antigen
• Clinical evaluation approaches
• Developmental immunotoxicity
• Health risk reduction
• Host resistance models
• Immunotoxicology testing
• Laboratory

From the reviews:

“This volume forms part of the Springer Protocols ‘Methods in Molecular Biology’ series … . All the chapters are quite well written, being concise and clearly laid out. … In conclusion, this is a useful laboratory professional’s ‘workshop manual’ for the most well-established immunotoxicity assays, focusing very much on the procedures at the laboratory bench. It will be a useful basic source of information for anyone starting to establish some of the test methods in their own laboratory.” (Peter R. Ryle, BTS Newsletter, Issue 37, Winter, 2010)

“In this book, Dr. Dietert of Cornell University has done an excellent job in covering concepts of immunotoxicology associated with analytical approaches to investigate mechanisms of toxicity and for the diagnosis of poisoning. Through very well-devised and illustrated texts by renowned researchers in immunotoxicology, the 26 chapters of this book cover the vast literature on approaches and strategies for immunotoxic testing, with detailed laboratory protocols. Thus, the book serves as a reference source for students, laboratory technicians and scientific researchers in toxicology.” (Sandra Farsky, Brazilian Journal of Pharmaceutical Sciences, May, 2010)

“This book provides a collection of testing approaches and strategies with detailed laboratory protocols in the successful style of the Methods in Molecular Biology series. … audience includes not only scientists working directly in the field of immunotoxicology, but also students, technicians, and lab and safety office personnel. … meant to be used by a specific subgroup of immunologists, the protocols are also used in many laboratory situations and are not limited to immunotoxicity studies. … The book appears to fill an important niche.” (Marion C. Cohen, Doody’s Review Service, September, 2010)

• College of Veterinary Medicine, Cornell University, Ithaca, U.S.A.

  Rodney R. Dietert

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