Methods in Molecular Biology

Mouse Models for Drug Discovery

Methods and Protocols

Editors: Proetzel, Gabriele, Wiles, Michael V. (Eds.)

  • Provides an excellent source for understanding the strength of the mouse as a model
  • Includes essential background about mouse genetic engineering
  • Covers the classic outbred and inbred mice as well as the latest genetically engineered mouse models
  • Surveys a wide range of mouse human disease models
  • Presents guidance from experimental design, techniques and approaches to data analysis
  • Describes the power of humanized mouse models
  • Highlights thorough protocols and techniques accompanied by useful illustrations as provided by experts in the field
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eBook $129.00
price for USA (gross)
  • ISBN 978-1-60761-058-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-60761-057-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies.  In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.


Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.

Reviews

From the reviews:

“This book details methods for drug delivery and common measurements using mouse and disease models. … useful to those who are interested in using mouse models in their research, particularly for those diseases discussed in the book. … many of the methods will be useful across diverse areas of research. … useful for researchers using mice to study diseases, particularly if they want to use new procedures. The descriptions of how to administer drugs using various methods are presented well. … the book is helpful.” (Karen M. Kassel, Doody’s Review Service, July, 2010)

Table of contents (24 chapters)

  • Improving Toxicity Screening and Drug Development by Using Genetically Defined Strains

    Festing, Michael F.W.

    Pages 1-21

  • The Sophisticated Mouse: Protecting a Precious Reagent

    Wiles, Michael V. (et al.)

    Pages 23-36

  • Genetically Engineered Mouse Models in Drug Discovery Research

    Sacca, Rosalba (et al.)

    Pages 37-54

  • Engineering the Mouse Genome to Model Human Disease for Drug Discovery

    Koentgen, Frank (et al.)

    Pages 55-77

  • Profiling of Drug Action Using Reporter Mice and Molecular Imaging

    Rando, Gianpaolo (et al.)

    Pages 79-92

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-1-60761-058-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-60761-057-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mouse Models for Drug Discovery
Book Subtitle
Methods and Protocols
Editors
  • Gabriele Proetzel
  • Michael V. Wiles
Series Title
Methods in Molecular Biology
Series Volume
602
Copyright
2010
Publisher
Humana Press
Copyright Holder
Humana Press
Distribution Rights
Distribution rights for India: Mehul Book Sales, Mumbai, India
eBook ISBN
978-1-60761-058-8
DOI
10.1007/978-1-60761-058-8
Hardcover ISBN
978-1-60761-057-1
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XII, 421
Topics