Cancer Drug Discovery and Development

Stem Cells and Cancer

Editors: Bagley, Rebecca G., Teicher, Beverly A. (Eds.)

  • Encompasses many aspects of stem cells as they pertain to cancer
  • Introduces the concept of cancer stem cells vs. normal stem cells
  • The first chapters describe the environmental niche where stem cells reside prior to being recruited to sites of tumorigenesis
  • Separate chapters distinguish hematopoietic stem cells from mesenchymal stem cells
  • The role of cancer stem cells in various forms of cancer is subsequently described and organized according to different indications, i.e., prostate, breast, colon, etc.
  • Experts in the field elaborate on molecular pathways that are critically involved in driving stem cell function
  • Finishes with new strategies that are being developed to overcome drug resistance by utilizing the knowledge gained from the investigations of cancer stem cells
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eBook $189.00
price for USA (gross)
  • ISBN 978-1-60327-933-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA
  • ISBN 978-1-60327-932-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA
  • ISBN 978-1-61737-920-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Significance of Stem Cells to Tumor Development

Cancer stem cells remain a controversial topic and the criteria that define cancer stem cells are continuing to evolve. A recent surge in stem cell research has ignited a field of discovery into many human diseases including diabetes, neuropathologies, and cancer. By replacing specific differentiated cells that have either been lost or died, stem cell therapy proves to be a very promising approach to the treatment of many debilitating diseases. Though stem cells may provide therapeutic benefit under certain conditions, they are also often implicated in the initiation, progression, and therapeutic resistance of malignant disease.

This first edition of Stem Cells and Cancer is intended to give a current perspective on the role of stem cells in cancer and strategies for novel therapies directed toward tumor stem cells. The current cancer stem cell hypothesis is presented in several chapters with distinctions made between the hierarchical and stochastic models of tumor cell development. "Stemness," self-renewal, pluripotency, clonality, and tumorigenicity are important concepts applied towards defining cancer stem cells. Signaling pathways such as Wnt, Sonic Hedgehog, Notch, and Bmi-1 that are involved in differentiation, proliferation, and survival are implicated in the malignant process. Additional chapters address the identification of cancer stem cell populations through the evaluation of molecular markers such as CD133, CD44, and CD24, for example, or by Hoescht dye exclusion to recognize ‘side populations.’ Mesenchymal and hematopoietic stem cells are described as well as mouse models that are employed to elucidate the properties and functionality of stem cells in cancer and the stem cell niche. This book encompasses a wide variety of human cancers that include but are not limited to leukemia, gliomas, breast, and prostate cancers. Resistance to conventional therapies, genetic versus epigenetic changes that affect therapeutic response and strategies to prevent disease recurrence are challenges have been incorporated into this volume. Stem Cells and Cancer represents a compendium of cutting edge research by experts in the field and will be instrumental in the study of this intriguing line of investigation for many years to come.

Rebecca Bagley is a senior scientist at Genzyme Corporation and has worked in the biotechnology industry for 20 years with degrees in biology from Wellesley College and Harvard University. Her expertise in drug development spans a wide range of approaches including immunotherapies,  gene and protein therapies, and small molecule delivery with publications in journals such as Molecular Cancer Therapeutics, Cancer Research, and Microvascular Research . Her current research focuses on stem cells, tumor vasculature, and target validation.

Dr. Beverly A. Teicher is Vice President of Oncology Research at Genzyme Corporation. Dr. Teicher completed a PhD in Bioorganic Chemistry at the Johns Hopkins University and postdoctoral training at Yale University School of Medicine. Dr. Teicher joined Dana-Farber Cancer Institute as an Assistant Professor of Pathology and rose to Associate Professor of Medicine and Radiation Therapy, Harvard Medical School at Dana-Farber Cancer Institute and Joint Center for Radiation Therapy. Dr. Teicher is an active member of the international scientific community having authored or co-authored more than 400 scientific publications. She has edited eight books, is senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.

Reviews

From the reviews: “This book … covers topics ranging from prostate cancer stem cells to targeting brain cancer stem cells in the clinic. … The book is written for a broad audience of basic science and clinical researchers interested in developmental biology and cancer cell biology. It will appeal to those interested in the promise of bioengineering using tissue-specific adult stem cells. … I enjoyed the wide diversity of topics, large readable font, and beautiful color plates. … The book is comprehensive yet readable.” (Bruce A. Fenderson, Doody’s Review Service, December, 2009)

Table of contents (24 chapters)

  • The Cancer Stem Cell Hypothesis

    Foreman, Kimberly E. (et al.)

    Pages 3-14

  • Tumor Stem Cells and Malignant Cells, One and the Same

    Teicher, Beverly A.

    Pages 15-26

  • Mesenchymal Stem Cells in Tumor Stroma

    Sullivan, Nicholas J. (et al.)

    Pages 29-36

  • Wnt Signaling in Cancer: From Embryogenesis to Stem Cell Self-Renewal

    Yagui-Beltrán, Adam (et al.)

    Pages 39-57

  • PTEN in Hematopoietic and Intestinal Stem Cells and Cancer

    Ross, Jason T. (et al.)

    Pages 59-73

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-60327-933-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA
  • ISBN 978-1-60327-932-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA
  • ISBN 978-1-61737-920-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Stem Cells and Cancer
Editors
  • Rebecca G. Bagley
  • Beverly A. Teicher
Series Title
Cancer Drug Discovery and Development
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60327-933-8
DOI
10.1007/978-1-60327-933-8
Hardcover ISBN
978-1-60327-932-1
Softcover ISBN
978-1-61737-920-8
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XVI, 346
Number of Illustrations and Tables
46 b/w illustrations, 16 illustrations in colour
Topics