Aging Medicine

Life-Span Extension

Single-Cell Organisms to Man

Editors: Sell, Christian, Lorenzini, Antonello, Brown-Borg, Holly M. (Eds.)

  • Multidisciplinary, with viewpoints of experts studying the aging process in species ranging from yeast to man
  • Discusses identification of common pathways that modulate longevity
  • Provides overview of recent, remarkable discoveries about underlying mechanisms important to aging
  • Explores studies in humans that have identified potentially important markers for successful aging
  • Discusses single mutations that extend life span and have been identified in yeast, worms, flies, and mice
  • Outlines emerging technologies and wide variety of systems that are now used to study aging
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eBook $179.00
price for USA (gross)
  • ISBN 978-1-60327-507-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-1-60327-506-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $229.00
price for USA
  • ISBN 978-1-61779-747-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process.

Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice.

Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.

Reviews

From the reviews: “This multiauthored book reviews the mechanisms of life-span extension across the animal kingdom, including man. … The audience here is researchers into the nature of aging and longevity. Many scientists looking at redox reactions in the body find themselves ultimately researching the nature of aging. For them, this is a useful guide. … This compact, well-edited book is a timely review of a complex subject.” (David O. Staats, Doody’s Review Service, April, 2010)

Table of contents (11 chapters)

  • Reprogramming Cell Survival and Longevity: The Role of Tor, Sch9, Ras, and Sir2

    Longo, Valter D.

    Pages 3-18

  • 2 Common Aging Mechanisms: Energy Metabolism and Longevity in Caenorhabditis elegans

    Artal-Sanz, Marta (et al.)

    Pages 21-32

  • 3 Conserved Mechanisms of Life-Span Regulation and Extension in Caenorhabditis elegans

    Curran, Sean P.

    Pages 33-56

  • The Genetic Architecture of Longevity

    Arking, Robert

    Pages 59-73

  • Mild Stress and Life Extension in Drosophila melanogaster

    Bourg, Éric Le

    Pages 75-88

Buy this book

eBook $179.00
price for USA (gross)
  • ISBN 978-1-60327-507-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-1-60327-506-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $229.00
price for USA
  • ISBN 978-1-61779-747-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Life-Span Extension
Book Subtitle
Single-Cell Organisms to Man
Editors
  • Christian Sell
  • Antonello Lorenzini
  • Holly M. Brown-Borg
Series Title
Aging Medicine
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60327-507-1
DOI
10.1007/978-1-60327-507-1
Hardcover ISBN
978-1-60327-506-4
Softcover ISBN
978-1-61779-747-7
Edition Number
1
Number of Pages
XVIII, 198
Number of Illustrations and Tables
20 b/w illustrations, 5 illustrations in colour
Topics