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Genetic Epidemiology

  • Book
  • © 2011

Overview

Editors:
  1. M. Dawn Teare

    1. School of Health and Related Research, Health Services Research, University of Sheffield, Sheffield, United Kingdom

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  • Aids researchers from various disciplines in communication and understanding with each other
  • Describes the fundamentals underlying the rapidly changing field
  • Provides advice from experts from a multitude of fields
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 713)

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Table of contents (17 protocols)

  1. Front Matter

    Pages i-xii
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Molecular Genetics and Genetic Variation

      • Mohammed-Elfatih Twfieg, M. Dawn Teare
      Pages 3-12

    3. Terminology, Concepts, and Models in Genetic Epidemiology

      • M. Dawn Teare, Mauro F. Santibàñez Koref
      Pages 13-25

    4. An Introduction to Epidemiology

      • Cother Hajat
      Pages 27-39

  3. Genetic Linkage Mapping

    1. Front Matter

      Pages 41-41
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    2. Genetic Distance and Markers Used in Linkage Mapping

      • Kristina Allen-Brady, Nicola J. Camp
      Pages 43-53

    3. Approaches to Genetic Linkage Analysis

      • M. Dawn Teare
      Pages 55-67

  4. Genetic Mapping by Association

    1. Front Matter

      Pages 69-69
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    2. Fine-Scale Structure of the Genome and Markers Used in Association Mapping

      • Karen Curtin, Nicola J. Camp
      Pages 71-88

    3. Genome-Wide Association Studies

      • Mark M. Iles
      Pages 89-103

    4. Candidate Gene Association Studies

      • M. Dawn Teare
      Pages 105-117

    5. Family-Based Association Studies

      • Frank Dudbridge
      Pages 119-127

    6. Genome Variation: A Review of Web Resources

      • Andrew Collins, William J. Tapper
      Pages 129-139

  5. Emerging Themes

    1. Front Matter

      Pages 141-141
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    2. Advanced Methods in Twin Studies

      • Jaakko Kaprio, Karri Silventoinen
      Pages 143-152

    3. Mendelian Randomisation: A Tool for Assessing Causality in Observational Epidemiology

      • Nuala A. Sheehan, Sha Meng, Vanessa Didelez
      Pages 153-166

    4. Copy Number Variation

      • Louise V. Wain, Martin D. Tobin
      Pages 167-183

    5. Epigenetic Variation

      • Kevin Walters
      Pages 185-197

  6. Case Studies

    1. Front Matter

      Pages 199-199
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Keywords

About this book

Arising from firm foundations laid by mathematical population genetics, clinical genetics, and statistical epidemiology, genetic epidemiology attempts to identify the many components of risk

attributable to genes, environments, and interactions, and the course of its research can follow many diverse paths.  In Genetic Epidemiology, the success of genome-wide association studies in their identification of hundreds of disease susceptibility loci has inspired renowned experts to contribute thorough methodologies, which aim to bring together bioinformaticians, geneticists, clinicians, statisticians, and epidemiologists in the study of this vital field.  The volume opens with chapters covering the basics; however, it quickly moves on to coverage of more specialist topics such as twin studies, Mendelian randomization, genetic association studies, more advanced areas, as well as case studies.  As a part of the highly successful Methods in Molecular Biology™ series, this work provides the detailed description of the application and analysis of the most commonly employed methods that are necessary for a firm grounding in the field.

 

Authoritative and cutting-edge, Genetic Epidemiology aims to provide a basic framework for crucial interdisciplinary communication and understanding suited to newcomers to the field as well as experienced researchers and graduate level students.

Editors and Affiliations

  • School of Health and Related Research, Health Services Research, University of Sheffield, Sheffield, United Kingdom

    M. Dawn Teare

Bibliographic Information

  • Book Title: Genetic Epidemiology

  • Editors: M. Dawn Teare

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-60327-416-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2011

  • Hardcover ISBN: 978-1-60327-415-9Published: 20 December 2010

  • Softcover ISBN: 978-1-4939-5709-5Published: 23 August 2016

  • eBook ISBN: 978-1-60327-416-6Published: 13 December 2010

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XII, 242

  • Topics: Human Genetics, Gene Function

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