Methods in Molecular Biology

Single Nucleotide Polymorphisms

Methods and Protocols

Editors: Komar, Anton A. (Ed.)

  • Fully updated from the first edition to offer cutting-edge methods for SNP detection and analysis
  • Offers a unique overview of next generation sequencing and genotyping approaches
  • Contains review chapters comparing method capabilities, error rates, and costs
  • Provides advanced techniques as well as descriptions of simple approaches which do not require sophisticated equipment
  • Low- and high-throughput, single and multiplex applications are presented
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eBook $129.00
price for USA (gross)
  • ISBN 978-1-60327-411-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-60327-410-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.00
price for USA
  • ISBN 978-1-61779-679-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In recent years, single nucleotide polymorphisms have received increased and special attention in a rapidly developing field of personalized medicine and drug treatment. Comprising more than eighty percent of all known polymorphisms, single nucleotide polymorphisms (SNPs) are primarily responsible for phenotypic differences between individuals, and have been suggested to affect the development of diseases in humans and the response to drug treatment and environmental stress. In Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition, expert researchers explore the latest advances in this area, highlighting the substantial progress that has been made in SNP genotyping, examining recent developments in high-throughput genotyping approaches, and exploring our new understanding of the impact of SNPs on gene function. Chapters address the impact of SNPs on phenotype, examine SNP databases, look at methods that have been applied for SNP bioinformatics discovery and analysis, and discuss advanced experimental approaches used for SNP detection. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.

Current and innovative, Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition is an essential guidebook for individual researchers as well as institutions and companies working in the field.

Reviews

From the reviews of the second edition:

“This second edition brings 11 new chapters … . Its target audience continues to be researchers and laboratory personnel. One helpful feature the book includes is a set of ‘notes’ at the end of each chapter … to be very useful for readers choosing to utilize a technique for the first time. … Overall, this book is a good addition to any laboratory setting actively working on complex human traits or interested in personalized medicine and drug treatments.” (Alexandre R. Vieira, Birth Defects Research (Part A): Clinical and Molecular Teratology, Vol. 88 (12), 2010)

Table of contents (28 chapters)

  • SNPs: Impact on Gene Function and Phenotype

    Shastry, Barkur S.

    Pages 3-22

  • Silent (Synonymous) SNPs: Should We Care About Them?

    Hunt, Ryan (et al.)

    Pages 23-39

  • SNP Databases

    Phillips, Christopher

    Pages 43-71

  • Mining SNPs from DNA Sequence Data; Computational Approaches to SNP Discovery and Analysis

    Oeveren, Jan (et al.)

    Pages 73-91

  • Next-Generation Sequencing Methods: Impact of Sequencing Accuracy on SNP Discovery

    Chan, Eugene Y.

    Pages 95-111

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-1-60327-411-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-60327-410-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.00
price for USA
  • ISBN 978-1-61779-679-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Single Nucleotide Polymorphisms
Book Subtitle
Methods and Protocols
Editors
  • Anton A. Komar
Series Title
Methods in Molecular Biology
Series Volume
578
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60327-411-1
DOI
10.1007/978-1-60327-411-1
Hardcover ISBN
978-1-60327-410-4
Softcover ISBN
978-1-61779-679-1
Series ISSN
1064-3745
Edition Number
2
Number of Pages
XIV, 464
Number of Illustrations and Tables
82 b/w illustrations, 18 illustrations in colour
Additional Information
Originally published as volume 212 in the series: Methods in Molecular Biology
Topics