Contemporary Clinical Neuroscience

Oxidative Neural Injury

Editors: Veasey, Sigrid C. (Ed.)

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  • ISBN 978-1-60327-342-8
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Hardcover $229.00
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  • ISBN 978-1-60327-341-1
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Softcover $229.00
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  • ISBN 978-1-61737-892-8
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About this book

Edited by
Sigrid Veasey, M.D.
Center for Sleep and Respiratory Neurobiology
Department of Medicine
University of Pennsylvania

Oxidative changes are observed in healthy aging of the nervous system, neurodegenerative processes and other forms of neural injury. At the same time, reactive oxygen species and reactive nitrogen species play critical roles in rapid response signaling, in learning, plasticity and in neuronal homeostasis. How do reactive oxygen and nitrogen molecules play such divergent roles in physiology and pathophysiology? How do these molecules contribute to neural injury, dysfunction and loss? The text Oxidative Neural Injury brings together international experts to systematically describe the biochemistry of reactive oxygen and nitrogen species signaling and then integrate this biochemistry into the neurobiology of redox in learning and plasticity and in healthy aging. This information will serve as the much-needed infrastructure for understanding in a more comprehensive manner how redox modifications contribute to neurodegenerative processes, in both early and late injury. Indeed, it is apparent that the development of effective therapies for neurodegenerative processes will first require a careful understanding of these critical roles of reactive oxygen and nitrogen molecules in neuronal signaling and cellular homeostasis, and this must be complemented with a comprehensive understanding of how reactive oxygen and nitrogen species perturb specific organelle and cellular functions.

Reviews

From the reviews: “This book addresses how oxidative stress contributes to age-related cellular dysfunction particularly in Alzheimer's ischemia, Parkinson's disease, and other neurodegenerative conditions. The book fills a niche, addressing the current molecular understanding of oxidative stress and its role in pathophysiology. … it is most appropriate for the many neuroscientists around the world contemplating how to identify the next best approach for targeted therapy for several neurodegenerative diseases. … the book is a good resource for libraries with PhD graduate students and molecular neuroscience laboratories.” (Joseph I. Sirven, Doody’s Review Service, December, 2009)

Table of contents (12 chapters)

  • Reactive Oxygen Species, Synaptic Plasticity, and Memory

    Kishida, Kenneth T. (et al.)

    Pages 1-27

  • Nitric Oxide Biochemistry: Pathophysiology of Nitric Oxide-Mediated Protein Modifications

    Rossi-George, Alba (et al.)

    Pages 29-44

  • Redox Imbalance in the Endoplasmic Reticulum

    Bánhegyi, Gábor (et al.)

    Pages 45-64

  • Exocytosis, Mitochondrial Injury and Oxidative Stress in Neurodegenerative Diseases

    Zanin, Mark P. (et al.)

    Pages 65-81

  • Neuronal Vulnerability to Oxidative Damage in Aging

    Okun, Eitan (et al.)

    Pages 83-95

Buy this book

eBook $179.00
price for USA (gross)
  • ISBN 978-1-60327-342-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-1-60327-341-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $229.00
price for USA
  • ISBN 978-1-61737-892-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Oxidative Neural Injury
Editors
  • Sigrid C. Veasey
Series Title
Contemporary Clinical Neuroscience
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60327-342-8
DOI
10.1007/978-1-60327-342-8
Hardcover ISBN
978-1-60327-341-1
Softcover ISBN
978-1-61737-892-8
Edition Number
1
Number of Pages
XIV, 218
Number of Illustrations and Tables
16 b/w illustrations
Topics