Cancer Drug Discovery and Development

Telomeres and Telomerase in Cancer

Editors: Hiyama, Keiko (Ed.)

  • Focuses on telomere and telomerase in human cancers
  • Provides medical doctors, pathologists, and translational cancer researchers with a deep understanding of these unique and fascinating molecules
  • Covers hot topics in clinical applications
see more benefits

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-60327-879-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-60327-306-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-888-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase positive cells, and consequence of telomerase inhibition are different among species. "Telomeres and Telomerase in Cancers", edited by Keiko Hiyama, focuses on "Human" telomeres and telomerase, from basic biology and hypothesis in human normal cells and cancer cells to clinical application as diagnostic tools and therapeutic targets in anti-cancer strategy. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer.

Table of contents (16 chapters)

  • Telomeres and Telomerase in Humans

    Hiyama, Keiko (et al.)

    Pages 3-21

  • Telomere-Binding Proteins in Humans

    Dimitrova, Nadya

    Pages 23-46

  • Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms

    Depcrynski, Amy N. (et al.)

    Pages 47-85

  • Telomere Dysfunction and the DNA Damage Response

    Diehl, Malissa C. (et al.)

    Pages 87-125

  • Alternative Lengthening of Telomeres in Human Cells

    Pickett, Hilda A. (et al.)

    Pages 127-148

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-60327-879-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-60327-306-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-888-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Telomeres and Telomerase in Cancer
Editors
  • Keiko Hiyama
Series Title
Cancer Drug Discovery and Development
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60327-879-9
DOI
10.1007/978-1-60327-879-9
Hardcover ISBN
978-1-60327-306-0
Softcover ISBN
978-1-61737-888-1
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XII, 380
Number of Illustrations and Tables
41 b/w illustrations, 19 illustrations in colour
Topics