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Cortico-Subcortical Dynamics in Parkinson’s Disease

  • Book
  • © 2009

Overview

Editors:
  1. Kuei-Yuan Tseng
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  • Multidisciplinary approaches
  • Provides critical reviews about mechanisms of neurodegeneration, particularly within the mesocortical/mesostriatal DA system

Part of the book series: Contemporary Neuroscience (CNEURO)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Cortico-Subcortical Circuits and Parkinson’s Disease

    1. Front Matter

      Pages 1-1
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    2. Leading Toward a Unified Cortico-basal Ganglia Functional Model

      • Shannon R. Blume, Kuei Y. Tseng
      Pages 1-20

    3. Modeling Parkinson’s Disease: 50 Years Later

      • Gloria E Meredith, Kuei Y Tseng
      Pages 23-34

  3. Physiological Studies of the Cortico-subcortical Dynamics and Parkinson’s Disease

    1. Front Matter

      Pages 1-1
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    2. Phasic Dopaminergic Signaling: Implications for Parkinson’s Disease

      • Stefan G. Sandberg, Paul E.M. Phillips
      Pages 37-54

    3. Striatal Dendritic Adaptations in Parkinson’s Disease Models

      • Michelle Day, D. James Surmeier
      Pages 55-71

    4. Diversity of Up-State Voltage Transitions During Different Network States

      • Nicolas Vautrelle, Luis Carrillo-Reid, José Bargas
      Pages 73-85

    5. The Corticostriatal Pathway in Parkinson’s Disease

      • Nigel S. Bamford, Carlos Cepeda
      Pages 87-104

    6. Cholinergic Interneuron and Parkinsonism

      • Dario Cuomo, Paola Platania, Giuseppina Martella, Graziella Madeo, Giuseppe Sciamanna, Annalisa Tassone et al.
      Pages 105-115

    7. Basal Ganglia Network Synchronization in Animal Models of Parkinson’s Disease

      • Judith R. Walters, Debra A. Bergstrom
      Pages 117-142

    8. Converging into a Unified Model of Parkinson’s Disease Pathophysiology

      • Camila L. Zold, Mariano Belluscio, Fernando Kasanetz, Pablo E. Pomata, Luis A. Riquelme, Francois Gonon et al.
      Pages 143-156

    9. The Corticostriatal Transmission in Parkinsonian Animals: In Vivo Studies

      • Bérangère Ballion, Nicolas Mallet, Catherine Le Moine, Mario Gustavo Murer, Francois Gonon
      Pages 157-169

    10. Striatal Nitric Oxide–cGMP Signaling in an Animal Model of Parkinson’s Disease

      • Anthony R. West, Stephen Sammut, Marjorie A. Ariano
      Pages 171-184

    11. Dopamine–Endocannabinoid Interactions in Parkinson’s Disease

      • Sarah E. McCallum, Joseph F. Cheer
      Pages 185-205

    12. Glutamate Plasticity in an Animal Model of Parkinson’s Disease

      • Charles K. Meshul
      Pages 207-230

  4. Computational Analyses of the Cortico-Subcortical Dynamics and Parkinson’s Disease

    1. Front Matter

      Pages 1-1
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    2. Neuromodulation and Neurodynamics of Striatal Inhibitory Networks: Implications for Parkinson’s Disease

      • Tomomi Shindou, Gordon W. Arbuthnott, Jeffery R. Wickens
      Pages 233-243

    3. Dopaminergic Modulation of Corticostriatal Interactions and Implications for Parkinson’s Disease

      • John A. Wolf, Jason T. Moyer
      Pages 245-258

  5. Neurobiology and Pathophysiology of Parkinson's Disease

    1. Front Matter

      Pages 1-1
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Keywords

About this book

The striatum is the principal input structure of the basal ganglia. Numerically, the great majority of neurons in the striatum are spiny projection neurons, which produce the inhibitory output of the striatum to the globus pallidum and substantia nigra. The major glutamatergic afferents to the striatum from the cerebral cortex make monosynaptic contact with spiny projection neurons. The dopaminergic afferents from the substantia nigra also synapse directly on the spiny projection neurons. Thus, the spiny projection neurons play a crucial role in the input–output operations of the striatum by integrating glutamatergic cortical inputs with dopaminergic inputs and producing the output to other basal ganglia nuclei. Anatomical observations made nearly 30 years ago suggested that inhibitory interactions among the spiny projection neurons of the striatum are very pr- able. Individual spiny projection neurons produce a local axonal plexus in the spheroidal space occupied by their own dendritic trees [1, 2]. Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network [3–5]. In the idealised concept of lateral inhibition, each output neuron makes inhibitory synaptic contact with its neighbours [5]. However, there are physical limitations set by the extent of axonal and dendritic trees, and the number of synaptic sites, which mean that lateral inhibition is limited to a local domain of inhibition.

Reviews

From the reviews:

"This book nicely combines up-to-date basic science information with clinical data on one of the most prevalent movement disorders worldwide - Parkinson’s disease (PD). … Written for specialists in Parkinson’s disease, the book is appropriate for movement disorder neurologists, neurosurgeons involved in the surgical management of Parkinson’s, and basic scientists interested in the anatomy, physiology, and neurochemistry of Parkinson’s. … It is most useful as a reference for basic scientists as well as clinical researchers." (Virgilio Gerald H. Evidente, Doody’s Review Service, September, 2009)

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