Methods in Molecular Biology

Drug'DNA Interaction Protocols

Editors: Fox, Keith (Ed.)

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About this book

In Drug-DNA Interactions, expert researchers describe powerful molecular techniques designed to illuminate and explore the interaction of drugs and ligands with DNA, often perfected in their own laboratories, . These easily reproducible methods involve sequence recognition properties, as well as physical approaches to measuring both the strength of interaction and the mode of drug binding to DNA. Drug interactions are also examined from a cellular perspective and for their usefulness in the development of new therapeutic agents.

Drug-DNA Interactions will be highly useful to all investigators needing the kind of detailed experimental and technical information often omitted from scientific papers. Those wishing to expand their repertoire of experimental techniques or to improve their current techniques will also find these powerful methods particularly helpful in elucidating the action of existing therapeutic agents, as well as in designing new anticancer drugs with improved action and reduced toxicity.






Reviews

"Methods in Molecular Biology is a long standing, respected series that provides protocols for the researcher. ..this particular book is a welcome addition for the researcher. It is recommended for all medical and science libraries."-Reviewer: H. Robert Malinowsky, E-STREAMS

Table of contents (18 chapters)

  • DNase I Footprinting

    Fox, Keith R.

    Pages 1-22

  • Quantitative DNA Footprinting

    Dabrowiak, James C. (et al.)

    Pages 23-42

  • Uranyl Photoprobing of DNA Structures and Drug–DNA Complexes

    Møllegaard, Niels Erik (et al.)

    Pages 43-49

  • Diethylpyrocarbonate and Osmium Tetroxide as Probes for Drug-Induced Changes in DNA Conformation In Vitro

    Bailly, Christian (et al.)

    Pages 51-79

  • Footprinting Studies with Nucleosome-Bound DNA

    Brown, Philip M. (et al.)

    Pages 81-93

Buy this book

eBook $79.99
price for USA (gross)
  • ISBN 978-1-59259-574-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
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Bibliographic Information

Bibliographic Information
Book Title
Drug'DNA Interaction Protocols
Editors
  • Keith Fox
Series Title
Methods in Molecular Biology
Series Volume
90
Copyright
1997
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-574-7
DOI
10.1385/089603447X
Series ISSN
1064-3745
Edition Number
1
Number of Pages
X, 278
Topics