Methods in Molecular Biology

Protein Structure Prediction

Methods and Protocols

Editors: Webster, David (Ed.)

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About this book

The deeper understanding of protein structure now emerging from cutting-edge research is not only illuminating evolutionary and biochemical mechanisms, but also promises enormous ramifications for molecular medicine, as well as for biotechnology, biophysics, biology, genetics, and other molecular sciences. In Protein Structure Prediction: Methods and Protocols, world-class investigators detail their most successful methods-and the theory behind them-for delineating the shape, form, and function of proteins. The protocols range from basic to advanced and include sequence alignment, the prediction of transmembrane protein structure, and the development of suitable folding potentials. There are also techniques for receptor site prediction, the identification of motifs and domains, the comparative modeling of proteins, the docking of peptides and ligands, and ab initio approaches to protein loop and side-chain prediction. To ensure robust and successful experimental results, each protocol contains step-by-step instructions, as well as tips on pitfalls to avoid and how procedures may be optimized for different systems.
Comprehensive, accessible, and highly practical, Protein Structure Prediction: Methods and Protocols offers protein researchers, structural biologists, and other investigators a critical synthesis of the latest research results, as well as the vital guidance needed to understand the structure and interaction of proteins and peptides.

Reviews

"The organization of this book is excellent. Eighteen chapters lead the reader through the entire process....Many of the authors are, in fact, the developers of some commonly used methods and offer a first-hand introduction to their software....The emphasis is on providing a practical handbook...most chapters contain detailed tutorials and worked-through examples that give a real-life flavor to the explanations."- Journal of American Chemical Society

"The book is a collection of 18 review articles, many written by distinguished experts in their field, providing an overview of the major aspects of protein structure prediction. About half of the articles deal with specific software packages, many of which are free to academic users, where the author of the software discussed....a useful reference to address for anyone thinking of dipping their toes into this exciting field." - Biochemistry and Molecular Biology Education

Table of contents (18 chapters)

  • Multiple Sequence Alignment

    Higgens, Desmond G. (et al.)

    Pages 1-18

  • Protein Structure Comparison Using SAP

    Taylor, William R.

    Pages 19-32

  • Discovering Patterns Conserved in Sets of Unaligned Protein Sequences

    Jonassen, Inge

    Pages 33-52

  • Identification of Domains from Protein Sequences

    Ponting, Chris P. (et al.)

    Pages 53-69

  • Third Generation Prediction of Secondary Structures

    Rost, Burkhard (et al.)

    Pages 71-95

Buy this book

eBook $79.99
price for USA (gross)
  • ISBN 978-1-59259-368-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
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Bibliographic Information

Bibliographic Information
Book Title
Protein Structure Prediction
Book Subtitle
Methods and Protocols
Editors
  • David Webster
Series Title
Methods in Molecular Biology
Series Volume
143
Copyright
2000
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-368-2
DOI
10.1385/1592593682
Series ISSN
1064-3745
Edition Number
1
Number of Pages
430
Topics