Current Clinical Neurology

Myasthenia Gravis and Related Disorders

Editors: Kaminski, Henry J. (Ed.)

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About this book

Myasthenia gravis, the best understood autoimmune disorder, serves as a model not only for study of the pathogenesis and treatment of all autoimmune diseases, but also for understanding synaptic function. In Myasthenia Gravis and Related Disorders, Henry J. Kaminski, MD, and an international panel of expert clinicians and leading scientists comprehensively review the clinical and basic science of this disease and its relatives, including acquired neuromyotonia and Lambert-Eaton syndrome. For the clinician, the book offers a rich portrait of the wide range of signs and symptoms that make these diseases difficult to diagnose. Replete with beautiful illustrations that carry the discussion well beyond the typical textbook, the authors review in depth the available diagnostic methods and their limitations, offer practical treatment recommendations based on years of experience, and discuss several promising treatment strategies now emerging. For the basic scientist, the text illuminates neuromuscular structure and function (the site of autoimmune pathology) and describes in detail the acetylcholine receptor (the central target of pathology in myasthenia gravis).
Authoritative and insightful, Myasthenia Gravis and Related Disorders follows this difficult illness from molecule to patient adaptation to illness, translating sophisticated evidence-based medicine into approaches directly useful in the doctor's office for effective patient diagnosis and treatment.

Reviews

"The book covers the physiology of the neuromuscular junction and of the ACR structure with detailed illustrations. There are extensive dissertations on the immunopathogenesis of myasthenia gravis, on the different immunogenetic properties of different thymona types, and finally on the different clinical presentations and therapeutic options. An entire chapter is devoted to when thymectomy is necessary and how it is performed. The chapter on myasthenia gravis crisis is concise and informative. This is a well organized, comprehensive book with abundant up-to-date references. It belongs in the library of any neurologist involved in the care of neuromuscular junction disorders." -Doody's Health Sciences Book Review Journal

"...a well rounded book. I think that neurologists in training and general neurologists wanting a refresher course could do a lot worse then read this text. I would certainly recommend it." - Brain: A Journal of Neurology

"Primarily this book will appeal to neurologists, clinical neurophysiologists, and neuroanaesthetists who will find it useful for their everyday clinical practice; researchers of neuromuscular junction disorders will also find the book interesting. This book is an up-to-date and valuable source of information on myasthenia and related disorders." -The Lancet

"Generally, the chapters are well-written, illustrations are appropriate, and the twenty-first century well represented in the references. The book is useful and up-to-date summary of all aspects of MG and its related disorders." -Muscle & Nerve

"This book is strongly recommended to clinicians and researchers dealing with neuromuscular disorders (and to thoracic surgeons performing thymectomy)." -Journal of Neurology, Neurosurgery, and Psychiatry

Table of contents (16 chapters)

  • Neuromuscular Junction Physiology and Pathophysiology

    Ruff, Robert L.

    Pages 1-13

  • Acetylcholine Receptor Structure

    Lindstrom, Jon M.

    Pages 15-52

  • Immunopathogenesis of Myasthenia Gravis

    Conti-Fine, Bianca M. (et al.)

    Pages 53-91

  • Clinical Presentation and Epidemiology of Myasthenia Gravis

    Kuks, Jan B. M. (et al.)

    Pages 93-113

  • Ocular Myasthenia

    Daroff, Robert B.

    Pages 115-128

Buy this book

eBook $69.99
price for USA (gross)
  • ISBN 978-1-59259-341-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
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Bibliographic Information

Bibliographic Information
Book Title
Myasthenia Gravis and Related Disorders
Editors
  • Henry J. Kaminski
Series Title
Current Clinical Neurology
Copyright
2003
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-341-5
DOI
10.1007/978-1-59259-341-5
Edition Number
1
Number of Pages
X, 396
Number of Illustrations and Tables
34 b/w illustrations, 3 illustrations in colour
Topics