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Tumor Models in Cancer Research

  • Book
  • © 2002

Overview

Editors:
  1. Beverly A. Teicher

    1. Lilly Research Laboratories, Indianapolis, USA

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-xv
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Perspective on the History of Tumor Models

      • Steadman Harrison
      Pages 3-19

  3. Transplantable Syngeneic Rodent Tumors

    1. Front Matter

      Pages 21-21
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    2. Murine L1210 and P388 Leukemias

      • Donald J. Dykes, William R. Waud
      Pages 23-40

    3. Transplantable Syngeneic Rodent Tumors

      • Thomas H. Corbett, Lisa Polin, Bill J. Roberts, Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White et al.
      Pages 41-71

    4. B16 Murine Melanoma

      • Enrique Alvarez
      Pages 73-89

  4. Human Tumor Xenografts

    1. Front Matter

      Pages 91-91
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    2. Xenotransplantation of Human Cell Cultures in Nude Mice

      • Beppino Giovanella
      Pages 93-97

    3. GFP-Expressing Metastatic-Cancer Mouse Models

      • Robert M. Hoffman
      Pages 99-112

    4. Human Tumor Xenografts and Explants

      • Heinz-Herbert Fiebig, Angelika M. Burger
      Pages 113-137

  5. Carcinogen-Induced Tumors

    1. Front Matter

      Pages 139-139
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    2. Hamster Oral Cancer Model

      • Joel Schwartz, Xinbin Gu
      Pages 141-171

    3. Mammary Cancer in Rats

      • Henry J. Thompson, Michael B. Sporn
      Pages 173-181

    4. Carcinogen-Induced Colon-Cancer Models for Chemoprevention and Nutritional Studies

      • Bandaru S. Reddy
      Pages 183-191

  6. Mutant, Transgenic, and Knockout Mouse Models

    1. Front Matter

      Pages 193-193
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    2. Cancer Models

      • John J. Letterio
      Pages 195-222

    3. Cyclin D1 Transgenic Mouse Models

      • Oliver G. Opitz, Hiroshi Nakagawa, Anil K. Rustgi
      Pages 223-230

    4. Mice Expressing the Human Carcinoembryonic Antigen

      • John W. Greiner
      Pages 231-246

    5. The p53-Deficient Mouse as a Cancer Model

      • Sundaresan Venkatachalam, Stuart Tyner, Lawrence A. Donehower
      Pages 247-261
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Keywords

About this book

Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Reviews

"...the book synthesizes years of knowledge on all major models available for cancer research. As a first comprehensive summary on tumor models in many years, it is certainly a good reference to those working in preclinical and clinical cancer research and drug development." -Pharmaceutical Research

"This publication belongs to the successful book series "Cancer Drug Discovery and Development™." The book provides an excellent guide over the experimental procedures developed in attempt to improve the treatment of malignancies. This publication represents an outstanding work devoted to the current state-of-the-art of the in vivo tumor models available for cancer research. The book will be of interest to oncologists, clinical and experimental cancer researchers. Practical approaches presented in the book, provide a guide to maximize the benefit for clinical anticancer treatment." - Neoplasma

Editors and Affiliations

  • Lilly Research Laboratories, Indianapolis, USA

    Beverly A. Teicher

Bibliographic Information

  • Book Title: Tumor Models in Cancer Research

  • Editors: Beverly A. Teicher

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-100-8

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Humana Press 2002

  • eBook ISBN: 978-1-59259-100-8Published: 07 November 2001

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XV, 690

  • Topics: Pharmacology/Toxicology

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