Cancer Drug Discovery and Development

Tumor Models in Cancer Research

Editors: Teicher, Beverly A. (Ed.)

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  • ISBN 978-1-59259-100-8
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About this book

Cancer researchers have made significant progress over the years by developing appropriate and accurate animal disease models, the most important being transplantable rodent tumors. In Tumor Models in Cancer Research, Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in tumor model research. The wide array of model systems detailed form the basis for the selection of both compounds and treatments that go into clinical testing of patients, and include syngeneic, human tumor xenograft, orthotopic, metastatic, transgenic, and gene knockout models. These models represent the efforts of many investigators over the years and approach, with increasing precision, examples that serve as guides for the selection of agents and combinations for the treatment of human malignancy.
Synthesizing many years of experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Reviews

"...the book synthesizes years of knowledge on all major models available for cancer research. As a first comprehensive summary on tumor models in many years, it is certainly a good reference to those working in preclinical and clinical cancer research and drug development." -Pharmaceutical Research

"This publication belongs to the successful book series "Cancer Drug Discovery and Developmentā„¢." The book provides an excellent guide over the experimental procedures developed in attempt to improve the treatment of malignancies. This publication represents an outstanding work devoted to the current state-of-the-art of the in vivo tumor models available for cancer research. The book will be of interest to oncologists, clinical and experimental cancer researchers. Practical approaches presented in the book, provide a guide to maximize the benefit for clinical anticancer treatment." - Neoplasma

Table of contents (34 chapters)

  • Perspective on the History of Tumor Models

    Harrison, Steadman

    Pages 3-19

  • Murine L1210 and P388 Leukemias

    Dykes, Donald J. (et al.)

    Pages 23-40

  • Transplantable Syngeneic Rodent Tumors

    Corbett, Thomas H. (et al.)

    Pages 41-71

  • B16 Murine Melanoma

    Alvarez, Enrique

    Pages 73-89

  • Xenotransplantation of Human Cell Cultures in Nude Mice

    Giovanella, Beppino

    Pages 93-97

Buy this book

eBook $69.99
price for USA (gross)
  • ISBN 978-1-59259-100-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Models in Cancer Research
Editors
  • Beverly A. Teicher
Series Title
Cancer Drug Discovery and Development
Copyright
2002
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-100-8
DOI
10.1007/978-1-59259-100-8
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XV, 690
Topics