Ophthalmology Research

Ocular Transporters in Ophthalmic Diseases and Drug Delivery

Editors: Tombran-Tink, Joyce, Barnstable, Colin J. (Eds.)

  • Focuses on the molecular characteristics, localization, and substrate spevidieis in various compartments of the eye of several classes of well-known membrane transporters
  • Illustrates how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness
  • Examines how epithelial and endothelial barriers can block drug delivery and limit ocular availability of drugs
see more benefits

Buy this book

eBook $259.00
price for USA (gross)
  • ISBN 978-1-59745-375-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $329.00
price for USA
  • ISBN 978-1-58829-958-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $329.00
price for USA
  • ISBN 978-1-62703-865-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye. Ocular Transporters in Ophthalmic Diseases and Drug Delivery is the first text book in this field and offers up-to-date information to clinicians, research scientists in academia, and the pharmaceutical industry. This work has clinical implications for drug development and therapeutic drug delivery, making it an invaluable resource for readers.

About the authors

Colin J. Barnstable, D.Phil., is Professor and Chair, Department of Neural and Behavioral Sciences
Director, Penn State Hershey Neuroscience Research Institute and Co-Director, Penn State Neuroscience Institute

Joyce Tombran-Tink, PhD, Department of Neural and Behavioral Sciences, Penn State Hershey Neuroscience Research Institute and Co-Director, Penn State Neuroscience Institute

Reviews

From the reviews: “The ophthalmic structures and tissues present a series of mechanisms necessary to homeostasis maintenance, in order to enable and support the vision function. … this book is indicated for physicians, pharmacologists, pharmacotechnicians, and investigators who wish to understand and study the complex processes of transportation and homeostasis of ocular globe, as well as to develop and formulate eye drops or apply therapies in the ophthalmology area.” (Vladi Olga Consiglieri, Brazilian Journal of Pharmaceutical Sciences, 2009)

Table of contents (24 chapters)

  • Aquaporins and Water Transport in the Cornea

    Verkman, Alan S.

    Pages 3-16

  • Roles of Corneal Epithelial Ion Transport Mechanisms in Mediating Responses to Cytokines and Osmotic Stress

    Reinach, Peter S. (et al.)

    Pages 17-46

  • Vitamin C Transport, Delivery, and Function in the Anterior Segment of the Eye

    Kannan, Ram (et al.)

    Pages 47-57

  • Mechanisms of Aqueous Humor Formation

    Do, Chi-wai (et al.)

    Pages 61-86

  • Membrane Transporters

    Donaldson, Paul J. (et al.)

    Pages 89-110

Buy this book

eBook $259.00
price for USA (gross)
  • ISBN 978-1-59745-375-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $329.00
price for USA
  • ISBN 978-1-58829-958-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $329.00
price for USA
  • ISBN 978-1-62703-865-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Ocular Transporters in Ophthalmic Diseases and Drug Delivery
Editors
  • Joyce Tombran-Tink
  • Colin J. Barnstable
Series Title
Ophthalmology Research
Copyright
2008
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-375-2
DOI
10.1007/978-1-59745-375-2
Hardcover ISBN
978-1-58829-958-1
Softcover ISBN
978-1-62703-865-2
Edition Number
1
Number of Pages
XVIII, 467
Topics