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Sourcebook of Models for Biomedical Research

  • Book
  • © 2008

Overview

Editors:
  1. P. Michael Conn

    1. Oregon National Primate Research Center, Beaverton
      Oregon Health and Science University, Portland

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  • Unique reflection of the diversity and utility of models used in biomedicine
  • Novel discussion of reproductive, mitotic, developmental or aging cycles in a range of organisms in comparison with humans
  • Insights on how some organisms that are able to grow in laboratory settings or lend themselves to convenient analyses have defined genomes or present especially good human models of human or animal disease
  • Uses a range of tables and figures to make comparisons of models so that observations not available in primary publications can become useful to the reader
  • Includes supplementary material: sn.pub/extras

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Table of contents (78 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Animal Models for Human Diseases

      • Jann Hau
      Pages 3-8

    3. Selection of Biomedical Animal Models

      • Michael S. Rand
      Pages 9-15

    4. Improved Models for Animal Research

      • Rolf Sprengel, Leonid Eshkind, Jan Hengstler, Ernesto Bockamp
      Pages 17-24

  3. General Considerations

    1. Front Matter

      Pages 25-25
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    2. The Ethical Basis for Animal Use in Research

      • James Parker
      Pages 27-33

    3. Bibliographic Searching Tools on Disease Models to Locate Alternatives for Animals in Research

      • Mary W. Wood, Lynette A. Hart
      Pages 35-41

    4. NIH Policies on Sharing of Model Organisms and Related Research Resources

      • J. P. Kim, Charlene Cho, Norka Ruiz Bravo
      Pages 43-48

    5. Databases for Biomedical Animal Resources

      • Richard L. Crawford, Tim Allen
      Pages 49-54

    6. Psychological Enrichment for Animals in Captivity

      • Kristine Coleman
      Pages 55-63

  4. Well-Established Models

    1. Front Matter

      Pages 65-65
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    2. Yeast, Worms, Flies, Sea Animals, and Birds

      1. Integrated Network Modeling of Molecular and Genetic Interactions
        • Gregory W. Carter, Vesteinn Thorsson, Timothy Galitski
        Pages 67-74
      2. The Sponge as a Model of Cellular Recognition
        • Xavier Fernàndez-Busquets
        Pages 75-83
      3. Sea Urchin Embryo
        • Tetsuya Kominami, Hiromi Takata
        Pages 85-90
      4. <i>Caenorhabditis elegans</i> Models of Human Neurodegenerative Diseases
        • Richard Nass, Lihsia Chen
        Pages 91-101
      5. Zebrafish as a Model for Development
        • Brian A. Link, Sean G. Megason
        Pages 103-112
      6. Zebrafish as a Model for Studying Adult Effects of Challenges to the Embryonic Nervous System
        • Nicole Marie Roy, Elwood A. Linney
        Pages 113-120
      7. Modeling Cognitive and Neurodegenerative Disorders in <i>Drosophila melanogaster</i>
        • Junjiro Horiuchi, Minoru Saitoe
        Pages 121-128
      8. Biomedical Research with Honey Bees
        • Michelle M. Elekonich
        Pages 129-138
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Keywords

About this book

The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.

Reviews

From the reviews:

"Conn, a distinguished scientist … has created one of the most significant and comprehensive model reference tools in recent years. … provides a system of relevancy that leads the serious student to adapt the model to their own different and perhaps unique research applications. The essays have a sufficient number of tables and overwhelmingly black-and-white figures and photographs to assist in comprehension. … Very useful for libraries serving upper-division and graduate students in the life sciences." (John M. Robson, American Reference Books Annual, 2009)

“Sourcebook of Models for Biomedical Research is a collection of the various models developed over several decades in biomedicine. … The chapters are presented clearly, easy to understand, and interesting to read. … In summary, this book would be a great addition to the library of anyone who is interested in an overview of model development for biomedical research.” (Dongwen Wang, The Quarterly Review of Biology, Vol. 85 (3), September, 2010)

Editors and Affiliations

  • Oregon National Primate Research Center, Beaverton

    P. Michael Conn

  • Oregon Health and Science University, Portland

    P. Michael Conn

Bibliographic Information

  • Book Title: Sourcebook of Models for Biomedical Research

  • Editors: P. Michael Conn

  • DOI: https://doi.org/10.1007/978-1-59745-285-4

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-933-8Published: 11 December 2007

  • eBook ISBN: 978-1-59745-285-4Published: 07 March 2008

  • Edition Number: 1

  • Number of Pages: XVI, 778

  • Number of Illustrations: 168 b/w illustrations, 12 illustrations in colour

  • Topics: Endocrinology, Biomedicine general, Neurosciences, Molecular Medicine

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