Overview
- Editors:
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David Posada
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Dept. Bioquímica, Genética e Inmunología, Universidad de Vigo, Vigo, Spain
- Provides practical guidance and troubleshooting advice for the computational analysis of DNA sequences
- Covers a wide range of methods that unveil the multitude of applications and relevance of bioinformatics today
- Includes worked examples with real data that will direct the reader in completing specific bionformatic analyses
- Does not require a special background in statistics, mathematics or computer science, only a basic knowledge of molecular biology and genetics
- Describes only tools which are free and can be downloaded or accessed through the web
- Most chapters could be used for practical advanced undergraduate or graduate-level courses in bioinformatics and molecular evolution
- Includes supplementary material: sn.pub/extras
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Table of contents (17 protocols)
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Front Matter
Pages i-xiii
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- Kit J. Menlove, Mark Clement, Keith A. Crandall
Pages 1-22
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- Mary Egan, Ernest K. Lee, Joanna C. Chiu, Gloria Coruzzi, Rob DeSalle
Pages 23-38
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- Kazutaka Katoh, George Asimenos, Hiroyuki Toh
Pages 39-64
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- Lars Sommer Jermiin, Joshua Wing Kei Ho, Kwok Wai Lau, Vivek Jayaswal
Pages 65-91
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- Stéphane Guindon, Frédéric Delsuc, Jean-François Dufayard, Olivier Gascuel
Pages 113-137
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- Christopher J. Creevey, James O. McInerney
Pages 139-161
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- Art F.Y. Poon, Simon D.W. Frost, Sergei L. Kosakovsky Pond
Pages 163-183
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- Jesse Zaneveld, Micah Hamady, Noboru Sueoka, Rob Knight
Pages 207-232
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- Federico Abascal, Rafael Zardoya, David Posada
Pages 233-242
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- Enrique Blanco, Josep F. Abril
Pages 243-261
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- Leonardo Mariño-Ramírez, Kannan Tharakaraman, John L. Spouge, David Landsman
Pages 263-276
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- Jacqueline Batley, David Edwards
Pages 303-321
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- Ahsan Huda, I. King Jordan
Pages 323-336
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Back Matter
Pages 351-354
About this book
The recent accumulation of information from genomes, including their sequences, has resultednotonlyinnewattemptstoansweroldquestionsandsolvelongstandingissues inbiology,butalsointheformulationofnovelhypothesesthatarisepreciselyfromthis wealth of data. The storage, processing, description, transmission, connection, and analysis of these data has prompted bioinformatics to become one the most relevant applied sciences for this new century, walking hand-in-hand with modern molecular biology and clearly impacting areas like biotechnology and biomedicine. Bioinformatics skills have now become essential for many scientists working with DNA sequences. With this idea in mind, this book aims to provide practical guidance andtroubleshootingadviceforthecomputationalanalysisofDNAsequences,covering a range of issues and methods that unveil the multitude of applications and relevance that Bioinformatics has today. The analysis of protein sequences has been purposely excludedtogainfocus.Individualbookchaptersareorientedtowardthedescriptionof theuseofspecificbioinformaticstools,accompaniedbypracticalexamples,adiscussion on the interpretation of results, and specific comments on strengths and limitations of the methods and tools. In a sense, chapters could be seen as enriched task-oriented manuals that will direct the reader in completing specific bioinformatics analyses. The target audience for this book is biochemists, and molecular and evolutionary biologiststhatwanttolearnhowtoanalyzeDNAsequencesinasimplebutmeaningful fashion. Readers do not need a special background in statistics, mathematics, or computer science, just a basic knowledge of molecular biology and genetics. All the tools described in the book are free and all of them can be downloaded or accessed throughtheweb.Mostchapterscouldbeusedforpracticaladvancedundergraduateor graduate-level courses in bioinformatics and molecular evolution.
Editors and Affiliations
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Dept. Bioquímica, Genética e Inmunología, Universidad de Vigo, Vigo, Spain
David Posada
