Contemporary Neuroscience

Opiate Receptors and Antagonists

From Bench to Clinic

Editors: Dean, Reginald, Bilsky, Edward J., Negus, S. Stevens (Eds.)

  • Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes
  • Highlights differences and similarities between the opioid pharmacology of animals and human
  • Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence
  • Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications
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eBook $189.00
price for USA (gross)
  • ISBN 978-1-59745-197-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-58829-881-2
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $249.00
price for USA
  • ISBN 978-1-61737-822-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The evolution in our understanding of Opioid receptors and their subtypes is intimately linked to the development of new pharmacological treatments for diseases and disorders as diverse as addiction, self-injurious behavior, pain, cancer, inflammation, eating disorders, traumatic injury, pruritis and movement disorders. The contributions contained in Opioid Receptors and Antagonists: From Bench to Clinic represent efforts from leading international scientists and clinicians making use of the latest information emerging from the study of the opioid-receptor system. The authors use a variety of experimental and clinical approaches involving the fields of molecular biology, biochemistry, anatomy, pharmacology, behavioral neuroscience and psychiatry to illustrate rapidly developing experimental and therapeutic areas. Highlights include characterization of opioid receptors, chemistry and pharmacology of opiod antagonists for various receptor subtypes (Mu, Kappa, and Delta), discussion of therapeutic uses of opiod antagonists and exploration of innovative approaches to therapeutic drug delivery.

Opioid Receptors and Antagonists: From Bench to Clinic offers a comprehensive view of recent work on opiod antagonist applications and uses in various clinical treatments. Emphasis is placed on disorders of the reward system. This volume serves as reference while also illuminating prospects for future research.

Reviews

From the reviews:

“The authors do an excellent job of providing insight into the background of the many factors related to opioid receptor antagonists. … Overall, this work is a well written and interesting text and would be a very useful addition to the personal libraries of those medicinal chemists with a research interest in the modulation of the opioid receptor system.” (Thomas E. Prisinzano, Journal of Medicinal Chemistry, Vol. 53 (2), March, 2010)

“This book is focused on the therapeutic uses of opioid antagonists ranging from classical opioid antagonists to novel chemical entities. In any therapeutic field examined, the aim of book as outlined by the title–‘From Bench to Clinic’–is achieved. … The clinical applications of opioid antagonists are extensively discussed in almost all chapters of this book … . In conclusion, this book gives an interesting analysis of the different fields of knowledge and research concerning therapeutic uses of opioid antagonists in recent years.” (Agostino Marrazzo, ChemBioChem, Vol. 5, 2010)


Table of contents (39 chapters)

  • Ultra-Low-Dose Opioid Antagonists Enhance Opioid Analgesia and Reduce Tolerance

    Burns, Lindsay H. (et al.)

    Pages 3-17

  • Upregulation of Opioid Receptors

    Unterwald, Ellen M. (et al.)

    Pages 19-44

  • Imaging Human Brain Opioid Receptors: Applications to Substance Use Disorders

    Greenwald, Mark K. (et al.)

    Pages 45-65

  • Opioid Receptor Antagonist-Mediated Signaling in the Immune System

    Moorman, Jonathan (et al.)

    Pages 67-80

  • The Chemistry and Pharmacology of μ-Opioid Antagonists

    Bidlack, Jean M. (et al.)

    Pages 83-97

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-59745-197-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-58829-881-2
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $249.00
price for USA
  • ISBN 978-1-61737-822-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Opiate Receptors and Antagonists
Book Subtitle
From Bench to Clinic
Editors
  • Reginald Dean
  • Edward J. Bilsky
  • S. Stevens Negus
Series Title
Contemporary Neuroscience
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-197-0
DOI
10.1007/978-1-59745-197-0
Hardcover ISBN
978-1-58829-881-2
Softcover ISBN
978-1-61737-822-5
Edition Number
1
Number of Pages
XXIII, 757
Topics