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Transforming Growth Factor-Beta in Cancer Therapy, Volume I

Basic and Clinical Biology

  • Book
  • © 2008

Overview

Authors:
  1. Sonia B. Jakowlew

    1. Cancer Training Branch, Office of Centers, Training and Resources, National Cancer Institute, Bethesda

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  • In-depth detail of basic concepts of TGF-ß in normal physiology and cancer pathobiology
  • Conveniently divided into three easy-to-follow parts
  • Companion volume details cancer treatments and therapies

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (45 chapters)

  1. Front Matter

    Pages i-xxiv
    Download chapter PDF

  2. Basic Concepts of TGF-β Signaling in Normal Physiology and Cancer Pathobiology

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Component Hardware for Transforming Growth Factor-β Signal Transduction: TGF-β Ligands, TGF-β Receptors, and Smads

      • Sonia B. Jakowlew
      Pages 3-21

    3. TGF-β Signaling in Homeostasis and Cancer

      • Joan Seoane
      Pages 23-35

    4. TGF-β Availability: Latent TGF-β and Latent TGF-β Binding Proteins

      • Vesna Todorovic, Daniel B. Rifkin
      Pages 37-55

    5. Biological Functions of Latent TGF-β-Binding Proteins and Activation of TGF-β

      • Marko Hyytiäinen, Katri Koli, Jorma Keski-Oja
      Pages 57-75

    6. Regulators of Smad2/3 Transcription and Phosphorylation

      • Azeddine Atfi, Marie-Francoise Bourgeade
      Pages 77-90

    7. Interaction of Smad4 and Embryonic Liver Fodrin-β-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression

      • Sang Soo Kim, Charles Shuman, Lopa Mishra
      Pages 91-103

    8. Regulation of Smad Activity by Phosphorylation

      • Fang Liu
      Pages 105-123

    9. Nuclear Targeting of TGF-β-Activated Smads in Normal and Tumor Biology

      • Lan Xu
      Pages 125-136

    10. Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival

      • Erwan Le Scolan, Kunxin Luo
      Pages 139-153

    11. Transforming Growth Factor-β in Cancer Therapy: Smurfs in TGF-β Signaling and Regulation of Bone Homeostasis and Cancer

      • Ying E. Zhang, Motozo Yamashita
      Pages 155-167

    12. Involvement of km23 Dynein Light Chains in TGF β Signaling

      • Qunyan Jin, Guofeng Gao, Kathleen M. Mulder
      Pages 169-184

    13. TGF-β Signaling in Fibroblastic Cells and Oncogenesis

      • Neil A. Bhowmick
      Pages 185-198

    14. Mechanisms of TGF-β-Induced Apoptosis in Cancer Cells

      • Tae-Aug Kim, Seong-Jin Kim
      Pages 199-211

    15. Mechanisms of Cell Cycle Regulation by TGF-β Disabled in Cancer

      • Leslie I. Gold, Jon Lecanda
      Pages 213-242

    16. Transforming Growth Factor-β in Cancer Therapy

      • Arja Band, Marikki Laiho
      Pages 243-257

    17. TGF-β and Smad Signaling in Transcriptome Reprogramming During EMT

      • Sylvie Thuault, Ulrich Valcourt, Marcin Kowanetz, Aristidis Moustakas
      Pages 259-273

    18. Functional Interactions Between MMPs and TGF-β in Normal and Tumor Tissue

      • Christina H. Stuelten, Anita B. Roberts, William G. Stetler-Stevenson
      Pages 275-292

    19. Cooperation Between TGF-β and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function

      • Irwin M. Liu, Stephen H. Schilling, Xiao-Fan Wang
      Pages 293-303
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Keywords

About this book

Transforming Growth Factor-jl in Cancer Therapy, Volume I: Basicand Clinical Biology The present volume brings together a wealth of information that is fundamental to understanding the roleofTGF-~ in the pathogenesis, prevention, and treatment of cancer. It is not even 25 years sinceTGF-~ was first isolated and characterized as a dimeric pep­ tide from both human and bovine sources (1-3), but the entire fieldofTGF-~ research has grown and expanded so that it is now a central theme in all of cell biology. There is almost no tissue or organ in the mammalian body in whichTGF-~ does not playa central role in embryonic differentiation or in adult function, and furthermore, malfunction of the normal physiologyofTGF-~can have disastrous consequences in almost all ofthese sites. Therefore, the present comprehensive review of so many aspects ofTGF-~ function is a most welcome attempt to bring together a huge body of experimental data that is of the utmost importance in the field of oncology.

Reviews

From the reviews:

"This volume provides a comprehensive review of TGF-beta regulation, signaling, and cellular function in both normal and tumor biology. … will be of use to individuals interested in the role of TGF-beta in the development of cancer and fibrosis. This will likely benefit readers interested in TGF-beta in the pathogenesis of disease … . also be a resource for those interested in the complex intracellular signaling cascades elicited by TGF-beta in normal and altered cells." (James P Luyendyk, Doody’s Review Service, May, 2008)

Authors and Affiliations

  • Cancer Training Branch, Office of Centers, Training and Resources, National Cancer Institute, Bethesda

    Sonia B. Jakowlew

Bibliographic Information

  • Book Title: Transforming Growth Factor-Beta in Cancer Therapy, Volume I

  • Book Subtitle: Basic and Clinical Biology

  • Authors: Sonia B. Jakowlew

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59745-292-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-714-3Published: 28 February 2008

  • Softcover ISBN: 978-1-61737-735-8Published: 19 November 2010

  • eBook ISBN: 978-1-59745-292-2Published: 01 January 2010

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XXIV, 735

  • Topics: Oncology, Cell Biology, Cancer Research, Pharmacology/Toxicology

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