Methods in Molecular Biology

Protein Design

Editors: Guerois, Raphael, de la Paz, Manuela López (Eds.)

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About this book

Recent major advances in our understanding of modulating protein functions has led to the development of new methods and algorithms to predict and decipher how amino acid sequences shape three-dimensional structures. Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success.
The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins. Other topics of discussion include: design of structural elementary motifs, entire proteins, and interfaces of protein complexes, and of amyloidogenic polypeptides and amyloid inhibitors.
Authoritative and cutting-edge, Protein Design: Methods and Applications will be of major interest to protein scientists, biochemists, and all experimentalists selecting the strategy most adaptable for their design problem.

Reviews

"...provides a comprehensive guide to the methods used at every stage of the protein-design process..." - ChemBioChem

"...combines a thorough theoretical foundation with detailed protocols and will be invaluable to all researchers in the area, from graduate students to senior investigators." -ChemBioChem


Table of contents (13 chapters)

  • Structure and Stability of the α-Helix

    Errington, Neil (et al.)

    Pages 3-26

  • De novo Design of Monomeric β-Hairpin and β-Sheet Peptides

    Pantoja-Uceda, David (et al.)

    Pages 27-51

  • De novo Proteins From Binary-Patterned Combinatorial Libraries

    Bradley, Luke H. (et al.)

    Pages 53-69

  • Non-Protein Amino Acids in the Design of Secondary Structure Scaffolds

    Mahalakshmi, Radhakrishnan (et al.)

    Pages 71-94

  • Design and Synthesis of β-Peptides With Biological Activity

    Koyack, Marc J. (et al.)

    Pages 95-109

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-1-59745-116-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-1-58829-585-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • ISBN 978-1-61737-659-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Protein Design
Editors
  • Raphael Guerois
  • Manuela López de la Paz
Series Title
Methods in Molecular Biology
Series Volume
340
Copyright
2006
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-116-1
DOI
10.1385/1597451169
Hardcover ISBN
978-1-58829-585-9
Softcover ISBN
978-1-61737-659-7
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIV, 300
Number of Illustrations and Tables
65 b/w illustrations
Topics