The Receptors

The Serotonin Receptors

From Molecular Pharmacology to Human Therapeutics

Editors: Roth, Bryan L. (Ed.)

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  • ISBN 978-1-59745-080-5
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Hardcover $369.00
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  • ISBN 978-1-58829-568-2
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Softcover $369.00
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  • ISBN 978-1-61737-647-4
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About this book

The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
Comprehensive and state of the art, The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics provides an illuminating "snapshot" of the 5-HT receptor field today and prospects for the future, taking it from the genomic to a systems level of understanding.

Reviews

From the reviews:

"This is a compilation of reviews regarding various aspects of serotonin receptor structure and function. … As a set of reviews, the book can be read by a broad scientific audience. Material of interest to senior scientists and research fellows is present. … Investigators wishing an up-to-date review of this field will find this book valuable. Those with selected interest, whether evolutionary or structural, will also find useful material. … is a good, comprehensive set of reviews. … overall, it is a valuable book." (Eugene A Davidson, Doody’s Review Service, February, 2007)


Table of contents (20 chapters)

  • Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin Receptors

    Kroeze, Wesley K. (et al.)

    Pages 1-38

  • Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes

    Westkaemper, Richard B. (et al.)

    Pages 39-58

  • Polymorphic and Posttranscriptional Modifications of 5-HT Receptor Structure

    Davies, Marilyn A. (et al.)

    Pages 59-90

  • Strategies for the Development of Selective Serotonergic Agents

    Glennon, Richard A.

    Pages 91-142

  • 5-HT Receptor Signal Transduction Pathways

    Turner, Justin H. (et al.)

    Pages 143-206

Buy this book

eBook $289.00
price for USA (gross)
  • ISBN 978-1-59745-080-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $369.00
price for USA
  • ISBN 978-1-58829-568-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $369.00
price for USA
  • ISBN 978-1-61737-647-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Serotonin Receptors
Book Subtitle
From Molecular Pharmacology to Human Therapeutics
Editors
  • Bryan L. Roth
Series Title
The Receptors
Copyright
2006
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-080-5
DOI
10.1007/978-1-59745-080-5
Hardcover ISBN
978-1-58829-568-2
Softcover ISBN
978-1-61737-647-4
Edition Number
1
Number of Pages
XVIII, 618
Number of Illustrations and Tables
77 b/w illustrations, 5 illustrations in colour
Topics