Contemporary Clinical Neuroscience

Transgenic and Knockout Models of Neuropsychiatric Disorders

Editors: Fisch, Gene S., Flint, Jonathan (Eds.)

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About this book

Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, as well as speech disorders, and disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Timely introductory articles debate the alleged continuity of species of human and infrahuman behavior (Darwin), the utility of infrahuman animals in understanding human behavior and psychiatric disease, and the suitability of nonhuman models of complex neuropsychiatric dysfunctions involving language.
Comprehensive and systematic, Transgenic and Knockout Models of Neuropsychiatric Disorders offers a clear assessment of whether genetic abnormalities produced from infrahuman models manifest the neuropsychiatric disorders to which they correspond in humans and how best they may be used to carry out successful research today.

Table of contents (13 chapters)

  • Transgenic and Knockout Models of Psychiatric Disorders

    Fisch, Gene S.

    Pages 3-23

  • Transgenic Mouse Models and Human Psychiatric Disease

    Flint, Jonathan

    Pages 25-43

  • Transgenic and Knockout Mouse Models

    Hayes, Linda J. (et al.)

    Pages 45-67

  • If Only They Could Talk

    Humby, Trevor (et al.)

    Pages 69-83

  • Spinocerebellar Ataxia Type 1

    Orr, Harry T.

    Pages 87-99

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-59745-058-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-58829-507-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-607-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Transgenic and Knockout Models of Neuropsychiatric Disorders
Editors
  • Gene S. Fisch
  • Jonathan Flint
Series Title
Contemporary Clinical Neuroscience
Copyright
2006
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-058-4
DOI
10.1007/978-1-59745-058-4
Hardcover ISBN
978-1-58829-507-1
Softcover ISBN
978-1-61737-607-8
Edition Number
1
Number of Pages
XII, 296
Number of Illustrations and Tables
20 b/w illustrations
Topics