Cancer Drug Discovery and Development

Gene Therapy for Cancer

Editors: Hunt, Kelly K., Vorburger, Stephan A., Swisher, Stephen G. (Eds.)

  • Vectors used in gene therapy for cancer
  • Characteristics and production methods of cancer gene vectors
  • Targets specific approaches for the therapy of cancer
  • Clinical applications of cancer gene therapy
  • Background knowledge, technical details, and preclinical and clinical results for cancer gene therapy
  • Provides a concise presentation of the current knowledge in cancer gene therapy
  • Will prove incredibly valuable as the volume of preclinical and clinical data continues to increase
see more benefits

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-59745-222-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-58829-472-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-590-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes. Unlike the treatment of genetic defects, where expr- sion of the corrected gene needs to be strong, permanent and, sometimes regulated, tactics to treat tumors can be based on temporary and locally limited effects. In addition, cancer cells have different properties than normal cells and this allows for targeting gene therapy to specific cells, a major advantage over current antitumor therapies, which are also toxic to normal cells and tissues.

Reviews

From the reviews:

"The book is divided into 3 sections. … this book is informative and provides a comprehensive review of the advances and limitations of cancer gene therapy. … Overall, the book provides enjoyable and instructive reading material. I highly recommend this book to scientists as well as clinicians as a reference source for cancer gene therapy. Readers would benefit from this excellent reading material, whether they are relatively new to this subspecialty or are actively working within the field of cancer gene therapy." (Prem Seth, JAMA, Vol. 299 (11), 2008)

"Gene Therapy for Cancer … covers the current technologies of cancer gene therapy as well as the difficult task of applying these in clinical trials. … The book also benefits through its helpful tables, drawings and illustrations. … Gene Therapy for Cancer provides a good overview of currently available techniques for cancer gene therapy and their limitations and potential for clinical applications. The book is a useful addition to the library of both researchers and clinicians working in the field." (S. Schepelmann and C. J. Springer, British Journal of Cancer, Vol. 98 (3), 2008)

“This new volume in Humana’s series is written for oncologists, hematologists, cancer researchers, geneticists.” (Tumori, Vol. 93, 2007)


Table of contents (25 chapters)

  • Adenovector-Mediated Cancer Gene Therapy

    Fang, Bingliang (et al.)

    Pages 3-22

  • Efficacy, Toxicity, and Immunogenicity of Adenoviral Vectors

    Shayakhmetov, Dmitry M.

    Pages 23-38

  • Lentiviral and Retroviral Vector Systems

    Stripecke, Renata (et al.)

    Pages 39-71

  • Vaccinia and Pox-Virus

    Chalikonda, Sricharan (et al.)

    Pages 73-85

  • Herpes Simplex Virus as a Therapy for Cancer

    Mohr, Ian J.

    Pages 87-108

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-59745-222-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-58829-472-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-590-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Gene Therapy for Cancer
Editors
  • Kelly K. Hunt
  • Stephan A. Vorburger
  • Stephen G. Swisher
Series Title
Cancer Drug Discovery and Development
Copyright
2007
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59745-222-9
DOI
10.1007/978-1-59745-222-9
Hardcover ISBN
978-1-58829-472-2
Softcover ISBN
978-1-61737-590-3
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XII, 469
Number of Illustrations and Tables
69 b/w illustrations, 16 illustrations in colour
Topics