Contemporary Clinical Neuroscience

The Orexin/Hypocretin System

Physiology and Pathophysiology

Editors: Nishino, Seiji, Sakurai, Takeshi (Eds.)

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eBook $229.00
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  • ISBN 978-1-59259-950-9
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Hardcover $289.00
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  • ISBN 978-1-58829-444-9
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Softcover $289.00
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  • ISBN 978-1-61737-574-3
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About this book

Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations.
Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.

Table of contents (27 chapters)

  • History and Overview of Orexin/Hypocretin Research

    Mieda, Michihiro (et al.)

    Pages 3-10

  • Orexin and Orexin Receptors

    Sakurai, Takeshi

    Pages 13-20

  • Orexin Projections and Localization of Orexin Receptors

    Marcus, Jacob N. (et al.)

    Pages 21-43

  • Neuronal Responses to Hypocretin/Orexin

    Pol, Anthony N. (et al.)

    Pages 45-60

  • Afferent System of Orexin Neurons

    Yamanaka, Akihiro

    Pages 61-70

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-59259-950-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-58829-444-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-574-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Orexin/Hypocretin System
Book Subtitle
Physiology and Pathophysiology
Editors
  • Seiji Nishino
  • Takeshi Sakurai
Series Title
Contemporary Clinical Neuroscience
Copyright
2005
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-950-9
DOI
10.1385/1592599508
Hardcover ISBN
978-1-58829-444-9
Softcover ISBN
978-1-61737-574-3
Edition Number
1
Number of Pages
416
Number of Illustrations and Tables
142 b/w illustrations, 9 illustrations in colour
Topics