Contemporary Clinical Neuroscience

The G Protein-Coupled Receptors Handbook

Editors: Devi, Lakshmi A. (Ed.)

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-59259-919-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-58829-365-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-522-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

G protein-coupled receptors (GPCRs) are involved in many processes in the human body relevant to health and disease, and consequently are the targets of approximately 70% of pharmacological therapeutics and a major source of new drug candidates. In The G Protein-Coupled Receptors Handbook, leading academic researchers comprehensively survey the many recent advances that have occurred in the GPCR field. The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors, and show how recent developments are leading to significant advances in drug discovery. They also discuss the most recent developments that could lead to new discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.
Authoritative and cutting-edge, The G Protein-Coupled Receptors Handbook offers pharmacologists, biochemists, and neuroscientists an exhaustive review of the progress made in understanding how GPCRs are activated and regulated, key factors in exploiting GPCRs for drug development.

Reviews

"...provides an excellent resource to introduce the reader to many of the diverse areas and questions that drive research in the GCPR field." -TRENDS in Endocrinology and Metablosim

Table of contents (18 chapters)

  • Structure—Function Relationships in G Protein-Coupled Receptors

    Massotte, Dominique (et al.)

    Pages 3-31

  • Molecular Mechanisms Involved in the Activation of Rhodopsin-Like Seven-Transmembrane Receptors

    Huang, Peng (et al.)

    Pages 33-70

  • GPCR Folding and Maturation

    Petäjä-Repo, Ulla E. (et al.)

    Pages 71-93

  • Regulated Membrane Trafficking and Proteolysis of GPCRs

    Hislop, James N. (et al.)

    Pages 95-105

  • Heterotrimeric G Proteins and Their Effector Pathways

    Hwangpo, Tracy Nguyen (et al.)

    Pages 109-134

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-59259-919-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-58829-365-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-522-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
The G Protein-Coupled Receptors Handbook
Editors
  • Lakshmi A. Devi
Series Title
Contemporary Clinical Neuroscience
Copyright
2005
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-919-6
DOI
10.1007/978-1-59259-919-6
Hardcover ISBN
978-1-58829-365-7
Softcover ISBN
978-1-61737-522-4
Edition Number
1
Number of Pages
XVI, 412
Number of Illustrations and Tables
47 b/w illustrations, 9 illustrations in colour
Topics