Current Clinical Oncology

Cancer Immunotherapy at the Crossroads

How Tumors Evade Immunity and What Can Be Done

Editors: Finke, James H., Bukowski, Ronald M. (Eds.)

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eBook $169.00
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  • ISBN 978-1-59259-743-7
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Hardcover $259.00
price for USA
  • ISBN 978-1-58829-183-7
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Softcover $219.00
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  • ISBN 978-1-4684-9844-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The growing evidence that tumors can evade the immune system through a variety of mechanisms makes understanding these processes critical to implementing new and more effective forms of immunotherapy. In Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done, leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors) that may serve as biomarkers for patient prognosis. They discuss the means by which immune functions may be protected or restored in order to more effectively support the process of tumor rejection in situ. Cutting-edge techniques with the capacity to monitor the strength and quality of patients' immune responses using immunocytometry, MHC-peptide tetramers combined with apoptosis assay, ELISPOT assay, and detection of MHC-TAA peptide complexes on tumor cells are also outlined.
State-of-the-art and insightful, Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done illuminates the possibilities for developing effective immunotherapies that can block the mechanisms by which tumors evade the immune system in different histologic types of tumors.

Reviews

"...good reading for all those interested in oncological immunotherapy." -Cancer Forum

"State of the art and insightful...illuminates the possibilities for developing effective immunotherapies that can block the mechanisms by which tumors evade the immune system in different histologic types of tumors." - Tumori

Table of contents (19 chapters)

  • HLA Class I Antigen-Processing Machinery and HLA Class I Antigen-Derived Peptide-Complex Defects in Tumor-Cell Escape

    Campoli, Michael (et al.)

    Pages 3-34

  • Immune Defects in T Cells From Cancer Patients

    Ochoa, Augusto C. (et al.)

    Pages 35-48

  • Malfunction of the Dendritic Cell System in Cancer

    Yurkovetsky, Zoya R. (et al.)

    Pages 49-65

  • CD4+ T-Cell-Mediated Immunity to Cancer

    Tatsumi, Tomohide (et al.)

    Pages 67-86

  • Immunological Ignorance in Cancer

    Tamada, Koji (et al.)

    Pages 87-99

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-59259-743-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-58829-183-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4684-9844-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cancer Immunotherapy at the Crossroads
Book Subtitle
How Tumors Evade Immunity and What Can Be Done
Editors
  • James H. Finke
  • Ronald M. Bukowski
Series Title
Current Clinical Oncology
Copyright
2004
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-743-7
DOI
10.1007/978-1-59259-743-7
Hardcover ISBN
978-1-58829-183-7
Softcover ISBN
978-1-4684-9844-8
Series ISSN
2364-1134
Edition Number
1
Number of Pages
XVII, 386
Topics