Cancer Drug Discovery and Development

Death Receptors in Cancer Therapy

Editors: El-Deiry, Wafik S. (Ed.)

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-59259-851-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-58829-172-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-61737-401-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.
Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.

Reviews

From the reviews:

"The book is resourceful for both basic scientists and clinicians, who are interested in developing targeted therapies for cancer. … the book is a valuable tool for researchers as well as to those of us involved in teaching apoptosis to undergraduate and graduate students." (Harikrishna Nakshatri, Leukemia Research, 2005)


Table of contents (21 chapters)

  • Mammalian Cell Death Pathways

    McDonald, E. Robert (et al.)

    Pages 1-41

  • Resistance to Apoptosis in Cancer Therapy

    McConkey, David J.

    Pages 43-64

  • Structures of TNF Receptors and Their Interactions With Ligands

    Hymowitz, Sarah G. (et al.)

    Pages 65-81

  • Death Receptor Signaling in Embryonic Ectodermal Development

    Chaudhary, Preet M.

    Pages 83-92

  • Adaptor Proteins in Death Receptor Signaling

    Chen, Nien-Jung (et al.)

    Pages 93-109

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-59259-851-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-58829-172-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-61737-401-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Death Receptors in Cancer Therapy
Editors
  • Wafik S. El-Deiry
Series Title
Cancer Drug Discovery and Development
Copyright
2005
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-851-9
DOI
10.1385/159259851X
Hardcover ISBN
978-1-58829-172-1
Softcover ISBN
978-1-61737-401-2
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XII, 374
Topics