Methods in Molecular Biology

Protein Misfolding and Disease

Editors: Bross, Peter, Gregersen, Niels (Eds.)

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About this book

It has now become clear that a large number of diseases with very different pathologies share a common framework of protein misfolding, accompanied by degradation and/or aggregation of the misfolded proteins. In Protein Misfolding and Disease: Principles and Protocols, notable experts in conformational disease review the latest thinking about the molecular processes underlying these diseases and describe cutting-edge biochemical, genomic, cellular, and chemical laboratory techniques for studying their genesis and pathologies. The authors apply their carefully refined methods to a variety of metabolic and neurodegenerative disorders, as well as to the aging process. The techniques presented are broadly applicable in many diverse disease contexts and may be used in both diagnosis and detailed research on new treatment strategies. Each tried and proven protocol includes insightful background notes, lists of required equipment and reagents, step-by-step instructions, and tips on troubleshooting and on how to avoid known pitfalls.
Comprehensive and cutting-edge, Protein Misfolding and Disease: Principles and Protocols offers both novice and experienced researchers a solid theoretical grounding in conformational disease and a remarkable set of analytical methodologies for uncovering its characteristics and generating new therapeutic approaches.

Reviews

"...a very sound book that provides a solid background in conformational disease and presents the reader with helpful experimental protocols for studying protein folding folding and misfolding." - Pharmaceutical Research

"...this book will be a very useful took for specialists in protein chemistry, molecular biology and basic medicine, and also for teachers and their students studying principles of proteomics." Biochemistry

Table of contents (24 chapters)

  • Protein Misfolding, Aggregation, and Degradation in Disease

    Gregersen, Niels (et al.)

    Pages 3-16

  • Basic Introduction to In Vivo Protein Folding and Its Defects

    Bross, Peter (et al.)

    Pages 17-26

  • Cystic Fibrosis

    Gelman, Marina S. (et al.)

    Pages 27-37

  • α1-Antitrypsin Deficiency

    Perlmutter, David H.

    Pages 39-56

  • Parkinson’s Disease

    Jakobsen, Lene Diness (et al.)

    Pages 57-66

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-1-59259-394-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-1-58829-065-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.00
price for USA
  • ISBN 978-1-61737-332-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Protein Misfolding and Disease
Editors
  • Peter Bross
  • Niels Gregersen
Series Title
Methods in Molecular Biology
Series Volume
232
Copyright
2003
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-394-1
DOI
10.1385/1592593941
Hardcover ISBN
978-1-58829-065-6
Softcover ISBN
978-1-61737-332-9
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XV, 318
Topics