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Thyroid Hormone Nuclear Receptor

Methods and Protocols

  • Book
  • © 2018

Overview

Editors:
  1. Michelina Plateroti

    1. Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France

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    You can also search for this editor in PubMed   Google Scholar

  2. Jacques Samarut

    1. École normale supérieure de Lyon, Lyon, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1801)

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Table of contents (22 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Thyroid Hormone Receptors: Several Players for One Hormone and Multiple Functions

    • Jacques Samarut, Michelina Plateroti
    Pages 1-8

  3. Two Protocols to Study the Interactions of Thyroid Hormone Receptors with Other Proteins and Chromatin

    • Wenyue Guan, Romain Guyot, Frédéric Flamant
    Pages 9-16

  4. Expression Analysis of Genes Regulated by Thyroid Hormone in Neural Cells

    • Juan Bernal, Beatriz Morte
    Pages 17-28

  5. In Vitro Approaches to Identify Thyroid Hormone Receptor-Dependent Transcriptional Response

    • Maria Sirakov, Michelina Plateroti
    Pages 29-38

  6. Posttranslational Modification of Thyroid Hormone Nuclear Receptor by Phosphorylation

    • Yan-Yun Liu, Gregory A. Brent
    Pages 39-46

  7. Posttranslational Modification of Thyroid Hormone Nuclear Receptor by Sumoylation

    • Yan-Yun Liu, Gregory A. Brent
    Pages 47-59

  8. Demonstration of the Receptor Site for Thyroid Hormone on Integrin αvβ3

    • Hung-Yun Lin, Shaker A. Mousa, Paul J. Davis
    Pages 61-65

  9. The Deiodinase Trio and Thyroid Hormone Signaling

    • Antonio C. Bianco, Rodrigo R. da Conceição
    Pages 67-83

  10. Thyroid Hormones and Derivatives: Endogenous Thyroid Hormones and Their Targets

    • Josef Köhrle
    Pages 85-104

  11. Protocols for Studying How Thyroid Hormone Receptors Trigger Adaptive Thermogenesis in Mice

    • Karine Gauthier
    Pages 105-110

  12. Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro

    • Jin Zhou, Rohit A. Sinha, Ronny Lesmana, Winifred W. Y. Yau, Paul M. Yen
    Pages 111-122

  13. Analysis of Physiological Responses to Thyroid Hormones and Their Receptors in Bone

    • J. H. Duncan Bassett, Graham R. Williams
    Pages 123-154

  14. Evaluating the Hypothalamic-Pituitary-Thyroid (HPT) Axis in Mice

    • F. E. Wondisford
    Pages 155-161

  15. Thyroid Hormone Action: The p43 Mitochondrial Pathway

    • Chantal Wrutniak-Cabello, François Casas, Gérard Cabello
    Pages 163-181

  16. Evaluating Thyroid Disrupting Chemicals In Vivo Using Xenopus laevis

    • Bilal B. Mughal, Barbara A. Demeneix, Jean-Baptiste Fini
    Pages 183-192

  17. Quantification of Thyromimetic Sobetirome Concentration in Biological Tissue Samples

    • Jordan Devereaux, Skylar J. Ferrara, Thomas S. Scanlan
    Pages 193-206

  18. Analysis of Thyroid Tumorigenesis in Xenograft Mouse Model

    • Xuguang Zhu, Sheue-Yann Cheng
    Pages 207-223

  19. Human Genetics of Thyroid Hormone Receptor Beta: Resistance to Thyroid Hormone Beta (RTHβ)

    • Theodora Pappa, Samuel Refetoff
    Pages 225-240

  20. TRα Mutations in Human

    • C. Briet, Natacha Bouhours-Nouet, F. Illouz, D. Prunier-Mirebeau, P. Rodien
    Pages 241-245
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Keywords

About this book

This volume aims to detail the advances in the field of Thyroid hormones (THs), namely T3 and T4, and their nuclear receptor TRs from a conceptual and methodological point of view. Chapters guide readers through a general introduction, TR's engineered mice, human genetics of TRs, control of the hypothalamus-pituitary-thyroid (HPT) axis, the relevance of the local THs production and metabolism and pathological consequences of TH/TR alterations. Non-mammalian models are also presented and discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and practical, Thyroid Hormone Nuclear Receptor: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Editors and Affiliations

  • Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France

    Michelina Plateroti

  • École normale supérieure de Lyon, Lyon, France

    Jacques Samarut

Bibliographic Information

  • Book Title: Thyroid Hormone Nuclear Receptor

  • Book Subtitle: Methods and Protocols

  • Editors: Michelina Plateroti, Jacques Samarut

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-7902-8

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2018

  • Hardcover ISBN: 978-1-4939-7901-1Published: 12 June 2018

  • Softcover ISBN: 978-1-4939-9320-8Published: 25 July 2019

  • eBook ISBN: 978-1-4939-7902-8Published: 11 June 2018

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XII, 300

  • Number of Illustrations: 18 b/w illustrations, 30 illustrations in colour

  • Topics: Molecular Medicine

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