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Extrasynaptic GABAA Receptors

  • Book
  • © 2014

Overview

Editors:
  1. Adam C. Errington

    1. Neuroscience and Mental Health Research Institute, Institute of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, United Kingdom

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  2. Giuseppe Di Giovanni

    1. Dept. of Physiology & Biochemistry, University of Malta, Msida MSD, Malta

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  3. Vincenzo Crunelli

    1. School of Biosciences, Cardiff University, Cardiff, United Kingdom

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  • First book to describe tonic inhibition
  • Emphasizes the important role of extrasynaptic GABAA receptors
  • Brings together contributions from leading experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: The Receptors (REC, volume 27)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-ix
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  2. Extrasynaptic GABAA Receptors

    • Adam C. Errington
    Pages 1-14

  3. Extrasynaptic GABAA Receptors: Subunit Composition, Distribution, and Regulation

    • Jean-Marc Fritschy, Patrizia Panzanelli
    Pages 15-32

  4. Biophysical Properties of Recombinant γ2- and δ-subunit Containing GABAA Receptors

    • Robert L. Macdonald, Emmanuel J. Botzolakis
    Pages 33-50

  5. The Pharmacology of Extrasynaptic GABAA Receptors

    • Keith A Wafford
    Pages 51-74

  6. Neurosteroids and Extrasynaptic GABAA Receptors

    • William M. Connelly
    Pages 75-84

  7. Sources of GABA That Activate Extrasynaptic GABAA Receptors

    • Damian Bright, Catriona Houston, Stephen Brickley
    Pages 85-124

  8. GPCR Modulation of Extrasynapitic GABAA Receptors

    • William M. Connelly, Adam C. Errington, Josue G. Yagüe, Anna Cavaccini, Vincenzo Crunelli, Giuseppe Di Giovanni
    Pages 125-153

  9. Extrasynaptic GABAA Receptors and Tonic Inhibition in Spinal Cord

    • Emanuel Loeza-Alcocer, Carmen Andrés, Justo Aguilar, Ricardo Felix, Rodolfo Delgado-Lezama
    Pages 155-178

  10. The Role of Peri-synaptic GABA Receptors After Stroke

    • Andrew N. Clarkson, Mary Chebib
    Pages 179-205

  11. The Role of Extrasynaptic GABAA Receptors in Focal Epilepsy

    • Matthew C. Walker, Ivan Pavlov
    Pages 207-221

  12. Gain-of-Function of Thalamic Extrasynaptic GABA-A Receptors in Typical Absence Seizures

    • Vincenzo Crunelli, Giuseppe Di Giovanni, H. Rheinallt Parri, Adam C. Errington
    Pages 223-237

  13. GABAergic Control of the Hypothalamic–Pituitary–Adrenal (HPA) Axis: Role of Extrasynaptic GABAA Receptors

    • Jamie Maguire
    Pages 239-270

  14. Tonic GABAA-Receptor-Mediated Inhibition in Fragile-X Syndrome: A Cause of Dysfunction or a Pathway for a Cure?

    • Brandon S. Martin, Molly M. Huntsman
    Pages 271-284

  15. Back Matter

    Pages 285-295
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Keywords

About this book

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Reviews

“This is an excellent monograph on the subject of GABA neurotransmission and GABA receptors in the synaptic and postsynaptic regions. … I highly recommend this book for neuroscientists, and neurophysiologists in an academic setting. It is of use for students, fellows, and postdoctoral scholars.” (Joseph J. Grenier, Amazon.com, May, 2015)

Editors and Affiliations

  • Neuroscience and Mental Health Research Institute, Institute of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, United Kingdom

    Adam C. Errington

  • Dept. of Physiology & Biochemistry, University of Malta, Msida MSD, Malta

    Giuseppe Di Giovanni

  • School of Biosciences, Cardiff University, Cardiff, United Kingdom

    Vincenzo Crunelli

Bibliographic Information

  • Book Title: Extrasynaptic GABAA Receptors

  • Editors: Adam C. Errington, Giuseppe Di Giovanni, Vincenzo Crunelli

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1007/978-1-4939-1426-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2014

  • Hardcover ISBN: 978-1-4939-1425-8Published: 23 September 2014

  • Softcover ISBN: 978-1-4939-5321-9Published: 23 August 2016

  • eBook ISBN: 978-1-4939-1426-5Published: 22 September 2014

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: IX, 295

  • Number of Illustrations: 16 b/w illustrations, 18 illustrations in colour

  • Topics: Neurosciences, Pharmacology/Toxicology, Neurology

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