Protein Tyrosine Phosphatases in Cancer

1. Front Matter

   Pages i-viii

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2. Time to Shine the Spotlight on the Protein Tyrosine Phosphatase Family of Signal Transducing Enzymes

   • Nicholas K. Tonks

   Pages 1-12

3. RPTPs and Cancer

   • Andrew W. Stoker

   Pages 13-45

4. Non-transmembrane PTPs in Cancer

   • Wiljan J. A. J. Hendriks, Frank-D Böhmer

   Pages 47-113

5. Role of PTPN11 (SHP2) in Cancer

   • Gordon Chan, Benjamin G. Neel

   Pages 115-143

6. The Role of TCPTP in Cancer

   • Tony Tiganis

   Pages 145-168

7. PTP1B: From Metabolism to Cancer

   • David P. Labbé, Michel L. Tremblay

   Pages 169-199

8. Dual-Specificity Map Kinase (MAPK) Phosphatases (MKPs) and Their Involvement in Cancer

   • Andrew M. Kidger, Stephen M. Keyse

   Pages 201-231

9. PTEN

   • Dawid G. Nowak, Lloyd C. Trotman

   Pages 233-246

10. Phosphatase-Independent Functions of the Tumor Suppressor PTEN

    • Antonella Papa, Pier Paolo Pandolfi

    Pages 247-260

11. The PRL PTPs: Regulating Gene Expression to Reprogram the Cancer Cell

    • Cameron A. Rogers, Catherine J. Pallen

    Pages 261-282

12. Cdc25 Family Phosphatases in Cancer

    • Brian Gabrielli, Andrew Burgess

    Pages 283-306

13. Protein-Tyrosine Phosphatases: Linking Metabolism and Cancer

    • Kendra K. Bence

    Pages 307-333

14. Current Status of PTP-Based Therapeutics

    • Rongjun He, Zhong-Yin Zhang

    Pages 335-353

15. Back Matter

    Pages 355-360

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This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts.

Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry. 

• Phosphatase
• SHP2
• TC-PTP
• PTEN
• CdC25

• Laura and Isaac Perlmutter Cancer Center, NY, USA

  Benjamin G. Neel

• Cold Spring Harbor Laboratory, Cold Spring Harbor, USA

  Nicholas K. Tonks

Dr. Neel earned his PhD in Viral Oncology from The Rockefeller University and his MD degree from Cornell University Medical School. After completing residency and post-doctoral training at Harvard institutions, he was appointed Assistant Professor of Medicine at Harvard Medical School (HMS), and began his own independent research laboratory in the Molecular Medicine Unit at Beth Israel Hospital in Boston, now known as Beth Israel Deaconess Medical Center (BIDMC). He also served as the Director of the Cancer Biology Program and as Deputy Director for Basic Research, Hematology Division at BIDMC. Currently, Dr. Neel is Director of the Laura and Isaac Perlmutter Cancer Center at New York University Langone Medical Center, as well as a Professor in the Department of Medicine at NYU.


Dr Neel is the author of over 160 original papers and 25 invited reviews. He was the inaugural recipient of the Gertrude Elion Award of the American Association for Cancer Research and holds an NIH MERIT award. His current scientific interests focus on cell signaling, with a particular emphasis on protein-tyrosine phosphatases (PTPs), as well as tumor stem cell signaling and the roles of Shp2 and its binding proteins in several human diseases. 


Dr Tonks was educated at Oxford University and the University of Dundee, where he earned his PhD. He subsequently conducted postdoctoral studies at the University of Washington with Edmond H.  Fischer, and moved to the Cold Spring Harbor Laboratory, where he was promoted to his current position of full Professor. 

Dr. Tonks has published over 180 papers in the field and has been granted 10 patents.  His research has been recognized by several awards, including a MERIT Award from the NIH and the Colworth Medal (British Biochemical Society).  He is a Fellow of the Royal Society and was a Pew Scholar in the Biomedical Sciences. Dr. Tonks' research focuses on functional analysis of members of the PTP family, using various approaches including RNA interference, in cell and animal models of disease.

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