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Mitochondria and Cell Death

  • Book
  • © 2016

Overview

Editors:
  1. David M. Hockenbery

    1. Clinical Research Divison, Fred Hutchinson Cancer Research Center, Seattle, USA

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  • Examines the role of mitochondria in cell death in one comprehensive volume
  • Discusses current understandings of the underlying mechanisms or cell death
  • Emphasizes the importance of mitochondrial dysfunction in pathogenesis of clinical diseases to bench-to-bedside investigations

Part of the book series: Cell Death in Biology and Diseases (CELLDEATH)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Lethal and Nonlethal Functions of the Permeability Transition Pore

    • Eric Fontaine, Paolo Bernardi
    Pages 1-15

  3. Mitochondrial Calcium and Ischemia: Reperfusion Injury in Heart

    • Liron Boyman, George S. B. Williams, W. Jonathan Lederer
    Pages 17-43

  4. Mislocalization of Mitochondrial Intermembrane Space Proteins

    • Lorna Flanagan, Federico Lucantoni, J. H. M. Prehn
    Pages 45-67

  5. Bcl-2 Protein Interplay on the Outer Mitochondrial Membrane

    • Frank Edlich, Jean-Claude Martinou
    Pages 69-83

  6. Remodeling of Mitochondria in Apoptosis

    • Guy A. Perkins, Mark H. Ellisman
    Pages 85-110

  7. Physiologic and Pathologic Functions of Mitochondrial ROS

    • Bryan G. Allen, Douglas R. Spitz
    Pages 111-130

  8. Mitochondrial Mutagenesis in Cancer

    • William J. Valente, Jason H. Bielas
    Pages 131-148

  9. Mitochondrial UPR in Cancer

    • Doris Germain
    Pages 149-167

  10. Mitochondrial Signaling

    • Nuno Raimundo, Lorena Fernandez-Mosquera, King Faisal Yambire
    Pages 169-186

  11. Mitochondria and Antiviral Immunity

    • Sunil Thomas, Michael Gale Jr.
    Pages 187-212

  12. Mitochondrial Permeabilization: From Lethality to Vitality

    • Andrew Oberst, Gabriel Ichim, Stephen W. G. Tait
    Pages 213-226

  13. Back Matter

    Pages 227-232
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Keywords

About this book

This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material.
 
Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology,as well as those interested in the study of mitochondria and cell biology.





Editors and Affiliations

  • Clinical Research Divison, Fred Hutchinson Cancer Research Center, Seattle, USA

    David M. Hockenbery

About the editor

David M. Hockenbery, MD is Professor, Member & Head of the Gastroenterology & Hepatology Section of the Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance. He is also a Mentor in the Seattle Children’s/UW/Hutchinson Center Pediatric Hematology-Oncology Fellowship Program. He received his M.D. from Washington University in St. Louis, completed his Residency in Medicine at Johns Hopkins and also completed two Fellowships, in Gastroenterology and Molecular Oncology, at Washington University. Dr. Hockenbery’s current research interests include the bcl-2 oncogene and its role in apoptosis, mitochondrial biology and bioenergetic metabolism, utilizing cell culture, transgenic mouse and protein biochemistry approaches for identification of cancer-selective metabolic pathways and discovery of small molecule inhibitors targeting these pathways.

Bibliographic Information

  • Book Title: Mitochondria and Cell Death

  • Editors: David M. Hockenbery

  • Series Title: Cell Death in Biology and Diseases

  • DOI: https://doi.org/10.1007/978-1-4939-3612-0

  • Publisher: Humana New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-3610-6Published: 04 July 2016

  • Softcover ISBN: 978-1-4939-8094-9Published: 30 May 2018

  • eBook ISBN: 978-1-4939-3612-0Published: 29 April 2016

  • Series ISSN: 2625-2902

  • Series E-ISSN: 2625-2899

  • Edition Number: 1

  • Number of Pages: XIV, 232

  • Number of Illustrations: 3 b/w illustrations, 23 illustrations in colour

  • Topics: Apoptosis, Membrane Biology, Cell Cycle Analysis

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