Springer celebrates 175 years of publishing excellence! Join us >>

Neuromethods

Designer Receptors Exclusively Activated by Designer Drugs

Editors: Thiel, Gerald (Ed.)

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
see more benefits

Buy this book

eBook n/a
  • ISBN 978-1-4939-2944-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-1-4939-2943-6
  • Free shipping for individuals worldwide
About this book

This volume provides current methods to analyze the properties of designer receptors exclusively activated by designer drugs (DREADDs) in vitro and to measure the biological responses of DREADD activation in different neuronal populations in vivo. Chapters focus on the utility of DREADD technology to selectively stimulate or inhibit neuronal activity in selected brain areas of transgenic mice. In addition, the successful use of DREADD expression in rats and Drosophila is described. Together, the DREADD technology represents a non-invasive, chemical-genetic tool for investigating neuronal signaling and the resulting behavioural responses in vivo. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use, Designer Receptors Exclusively Activated by Designer Drugs aims to ensure successful results in the further study of this vital field.

Table of contents (9 chapters)

  • Defining the Functional Equivalence of Wild-Type and Chemically Engineered G Protein-Coupled Receptors

    Alvarez-Curto, Elisa (et al.)

    Pages 1-28

  • Design and Analysis of an Arrestin-Biased DREADD

    Nakajima, Ken-ichiro (et al.)

    Pages 29-48

  • Regulation of Gene Transcription Following Stimulation of Gαq-Coupled Designer Receptors

    Rössler, Oliver G. (et al.)

    Pages 49-60

  • Chemogenetic Deconstruction of Feeding Circuits

    Krashes, Michael

    Pages 61-81

  • Dissecting Neuronal Circuits Involved in Olfactory-Mediated Behaviors

    Nunez-Parra, Alexia (et al.)

    Pages 83-94

Buy this book

eBook n/a
  • ISBN 978-1-4939-2944-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-1-4939-2943-6
  • Free shipping for individuals worldwide
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Designer Receptors Exclusively Activated by Designer Drugs
Editors
  • Gerald Thiel
Series Title
Neuromethods
Series Volume
108
Copyright
2015
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-2944-3
DOI
10.1007/978-1-4939-2944-3
Hardcover ISBN
978-1-4939-2943-6
Series ISSN
0893-2336
Edition Number
1
Number of Pages
XVII, 160
Number of Illustrations and Tables
14 b/w illustrations, 14 illustrations in colour
Topics