Methods in Molecular Biology

Systems Biology of Alzheimer's Disease

Editors: Castrillo, Juan I., Oliver, Stephen G. (Eds.)

  • Includes cutting-edge systems biology methods and protocols for neuroscientific study
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
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About this book

Alzheimer’s disease (AD) and many other neurodegenerative disorders are multifactorial in nature, involving a combination of genomic, epigenomic, network dynamic and environmental factors. A proper investigation requires new integrative Systems Biology approaches, at both the experimental and computational level. The interplay of disease mechanisms and homeostatic networks will underlie the time of onset and rate of progression of the disease.

This book addresses such an integrated approach to AD. It aims to present Systems Biology, including both experimental and computational approaches, as a new strategy for the study of AD and other multifactorial diseases, with the hope that the results will translate into more effective diagnosis and treatment, as well as improved public health policies.

Written for the highly successful Methods in Molecular Biology series, practical and cutting-edge, Systems Biology of Alzheimer’s Disease is intended for post-graduate students, post-doctoral researchers and experts in different fields with an interest in comprehensive Systems Biology strategies applicable to AD and other complex multifactorial diseases (including other neurodegenerative diseases and cancers). This book aims to complement other excellent volumes and monographs on AD that cover fundamental, physiological or medical aspects of the disease.

About the authors

Stephen G. Oliver

Department of Biochemistry & Cambridge Systems Biology Centre

University of Cambridge

Cambridge UK

steve.oliver@bioc.cam.ac.uk

 

Juan I. Castrillo

Department of Biochemistry & Cambridge Systems Biology Centre

University of Cambridge

Cambridge UK

 

Genetadi Biotech S.L. Praque

Tecnologico de Bizkaia

Derio, Bizkaia, Spain

jicd28@yahoo.co.uk   

jic28@genetadi.com

 

Reviews

“The book represents a very useful introduction to Systems Biology as the approach necessary to obtain a global view of the dysregulation of pathways involved in AD. In the need for standardization of techniques, the methods described in this book provide a step forward in the definition of common guidelines leading to the reproducible and dependable results necessary for a better understanding of the pathophysiology of AD.” (Dr. Alessandro Villa, Journal of Alzheimer's Disease, Vol. 50, 2016)


Table of contents (33 chapters)

  • Alzheimer’s as a Systems-Level Disease Involving the Interplay of Multiple Cellular Networks

    Castrillo, Juan I. (et al.)

    Pages 3-48

  • Application of Systems Theory in Longitudinal Studies on the Origin and Progression of Alzheimer’s Disease

    Lista, Simone (et al.)

    Pages 49-67

  • The APP Proteolytic System and Its Interactions with Dynamic Networks in Alzheimer’s Disease

    Hunter, Sally (et al.)

    Pages 71-99

  • Effects of Mild and Severe Oxidative Stress on BACE1 Expression and APP Amyloidogenic Processing

    Tan, Jiangli (et al.)

    Pages 101-116

  • Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models

    García-Osta, Ana (et al.)

    Pages 117-123

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-1-4939-2627-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-1-4939-2626-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
  • ISBN 978-1-4939-4703-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Systems Biology of Alzheimer's Disease
Editors
  • Juan I. Castrillo
  • Stephen G. Oliver
Series Title
Methods in Molecular Biology
Series Volume
1303
Copyright
2016
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-2627-5
DOI
10.1007/978-1-4939-2627-5
Hardcover ISBN
978-1-4939-2626-8
Softcover ISBN
978-1-4939-4703-4
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XVI, 563
Number of Illustrations and Tables
18 b/w illustrations, 56 illustrations in colour
Topics