Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2

1. Front Matter

   Pages i-xi

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2. Fungal Secondary Metabolites in the “OMICS” Era

   • Susanne Zeilinger, Carlos García-Estrada, Juan-Francisco Martín

   Pages 1-12

3. Key Players in the Regulation of Fungal Secondary Metabolism

   • Benjamin P. Knox, Nancy P. Keller

   Pages 13-28

4. Epigenetics of Fungal Secondary Metabolism Related Genes

   • Ming-Yueh Wu, Jae-Hyuk Yu

   Pages 29-42

5. Genome Mining for Fungal Secondary Metabolic Gene Clusters

   • Grayson T. Wawrzyn, Mark A. Held, Sarah E. Bloch, Claudia Schmidt-Dannert

   Pages 43-65

6. Metagenomics and Metatranscriptomics for the Exploration of Natural Products from Soil Fungi

   • Irshad Ul Haq, Jan Dirk van Elsas

   Pages 67-79

7. Metabolomics and Secondary Metabolite Profiling of Filamentous Fungi

   • Bernhard Kluger, Sylvia Lehner, Rainer Schuhmacher

   Pages 81-101

8. Fungal Chemotaxonomy

   • Jens C. Frisvad

   Pages 103-121

9. Endophytic Fungi as a Source of Novel Metabolites

   • Fernanda O. Chagas, Andrés Mauricio Caraballo-Rodriguez, Mônica T. Pupo

   Pages 123-176

10. Fungal Secondary Metabolism in the Light of Animal–Fungus Interactions: From Mechanism to Ecological Function

    • Marko Rohlfs

    Pages 177-198

11. Fusarium Mycotoxins and Their Role in Plant–Pathogen Interactions

    • Gerhard Adam, Gerlinde Wiesenberger, Ulrich Güldener

    Pages 199-233

12. Biosynthesis and Molecular Genetics of Peptaibiotics—Fungal Peptides Containing Alpha, Alpha-Dialkyl Amino Acids

    • Xiao-Yan Song, Bin-Bin Xie, Xiu-Lan Chen, Yu-Zhong Zhang

    Pages 235-252

13. Back Matter

    Pages 253-256

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​Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.

• Fungal Biology
• Fungal Development
• Fungal genomics
• Secondary Metabolism
• metabolomics of fungi

• Institute of Chemical Engineering, Vienna University of Technology, Vienna, Austria

  Susanne Zeilinger

• Department of Molecular Biology, University of León, León, Spain

  Juan-Francisco Martín

• Biomedicine and Biopharma Area (INBIOTEC), Instituto de Biotecnología de León, León, Spain

  Carlos García-Estrada

Juan-Francisco Martín, PhD
University of León, Department of Molecular Biology, Area of Microbiology, León, Spain

Carlos García-Estrada, DVM, PhD 
Institute of Biotechnology of León (INBIOTEC), Parque Científico de León, León, Spain

Susanne Zeilinger, PhD
Vienna University of Technology, Institute of Chemical Engineering, Vienna, Austria

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