Humanized Mice for HIV Research

Editors: Poluektova, L.Y., Garcia-Martinez, J.V., Koyanagi, Y., Manz, M.G., Tager, A.M. (Eds.)

  • ​Features mouse-to-human xenotransplantation/cross-reactivity of immune systems
  • Assesses the applicability of different mouse genetic backgrounds for humanization and human immune system function
  • Written by doctors who have worked in many different areas of HIV-1 research
see more benefits

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-1-4939-1655-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-1-4939-1654-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
  • ISBN 978-1-4939-4563-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria.

Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.

About the authors

Larisa Y. Poluektova, University of Nebraska Medical Center, Omaha, USA

J. Victor Garcia, University of North Carolina at Chapel Hill, USA

Yoshio Koyanagi, Kyoto University, Japan

Markus G. Manz, University Hospital Zürich, Switzerland

Andrew M. Tager, Massachusetts General Hospital and Ragon Institute of MGH, MIT and Harvard, USA). 

Reviews

“Humanized Mice for HIV Research is a comprehensive overview of human immune engrafted mouse models as they apply to HIV, but also with relevance to other fields of study. … Although the work is titled, this book also includes a section on modeling other human specific/selection pathogens in human immune system mice. … Humanized Mice for HIV Research is an excellent reference, not just for HIV researchers, but also for anyone interested in working with immune engrafted models.” (Megan M. MacBride, Taconic Biosciences, taconic.com, January, 2016)


Table of contents (42 chapters)

  • Mamoru Ito’s Vision for the Future of Humanized Mouse Models

    Ito, Mamoru

    Pages 1-12

  • Humanized Mice as Models for Human Disease

    McCune, Joseph M. (et al.)

    Pages 15-24

  • Role of Mouse Innate Immunity in Immunodeficient Mice for Xenotransplantation

    Ito, Ryoji (et al.)

    Pages 25-32

  • Mouse Genetic Background and Human Hematopoietic Stem Cells Biology; Tips for Humanization

    Kovtonyuk, Larisa V. (et al.)

    Pages 33-51

  • Biology of Human Hematopoietic Stem Cell Xenotransplantation in Mice

    Hu, Zheng (et al.)

    Pages 53-60

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-1-4939-1655-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-1-4939-1654-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
  • ISBN 978-1-4939-4563-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Humanized Mice for HIV Research
Editors
  • Larisa Y Poluektova
  • J. Victor Garcia-Martinez
  • Yoshio Koyanagi
  • Markus G. Manz
  • Andrew M. Tager
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-1655-9
DOI
10.1007/978-1-4939-1655-9
Hardcover ISBN
978-1-4939-1654-2
Softcover ISBN
978-1-4939-4563-4
Edition Number
1
Number of Pages
XXI, 538
Number of Illustrations and Tables
9 b/w illustrations, 45 illustrations in colour
Topics