Biological and Medical Physics, Biomedical Engineering

The Physical Basis of Bacterial Quorum Communication

Editors: Hagen, Stephen J. (Ed.)

  • Analyzes bacterial quorum sensing from a physical and mathematical perspective
  • Explores the role of spatiotemporal diffusion, regulatory dynamics, stochasticity and information in quorum communication
  • Includes contributions from leading experimentalists, theoreticians, engineers and modelers
  • Takes a physical science and engineering approach to the subject, but will appeal to anyone with a background in physical biology
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eBook $139.00
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  • ISBN 978-1-4939-1402-9
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Hardcover $179.00
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  • ISBN 978-1-4939-1401-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
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  • ISBN 978-1-4939-4736-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Quorum sensing (QS) describes a chemical communication behavior that is nearly universal among bacteria. Individual cells release a diffusible small molecule (an autoinducer) into their environment. A high concentration of this autoinducer serves as a signal of high population density, triggering new patterns of gene expression throughout the population. However QS is often much more complex than this simple census-taking behavior. Many QS bacteria produce and detect multiple autoinducers, which generate quorum signal cross talk with each other and with other bacterial species. QS gene regulatory networks respond to a range of physiological and environmental inputs in addition to autoinducer signals. While a host of individual QS systems have been characterized in great molecular and chemical detail, quorum communication raises many fundamental quantitative problems which are increasingly attracting the attention of physical scientists and mathematicians.  Key questions include: What kinds of information can a bacterium gather about its environment through QS? What physical principles ultimately constrain the efficacy of diffusion-based communication?  How do QS regulatory networks maximize information throughput while minimizing undesirable noise and cross talk? How does QS function in complex, spatially structured environments such as biofilms?  Previous books and reviews have focused on the microbiology and biochemistry of QS. With contributions by leading scientists and mathematicians working in the field of physical biology,  this volume examines the interplay of diffusion and signaling, collective and coupled dynamics of gene regulation, and spatiotemporal QS phenomena. Chapters will describe experimental studies of QS in natural and engineered or microfabricated bacterial environments, as well as modeling of QS on length scales spanning from the molecular to macroscopic. The book aims to educate physical scientists and quantitative-oriented biologists on the application of physics-based experiment and analysis, together with appropriate modeling, in the understanding and interpretation of the pervasive phenomenon of microbial quorum communication.

Table of contents (12 chapters)

  • Introduction

    Hagen, Stephen J.

    Pages 1-5

  • Modeling of Signal Transduction by the Quorum-Sensing Pathway in the Vibrios

    Bandyopadhyay, Arnab (et al.)

    Pages 7-18

  • Stochastic Effects in Quorum Sensing

    Weber, Marc (et al.)

    Pages 19-52

  • Spatial Structure of Microbes in Nature and the Biophysics of Cell–Cell Communication

    Boedicker, James Q. (et al.)

    Pages 53-81

  • Functionality of Autoinducer Systems in Complex Environments

    Hense, B. A. (et al.)

    Pages 83-103

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-1-4939-1402-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-1-4939-1401-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • ISBN 978-1-4939-4736-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Physical Basis of Bacterial Quorum Communication
Editors
  • Stephen J. Hagen
Series Title
Biological and Medical Physics, Biomedical Engineering
Copyright
2015
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-1402-9
DOI
10.1007/978-1-4939-1402-9
Hardcover ISBN
978-1-4939-1401-2
Softcover ISBN
978-1-4939-4736-2
Series ISSN
1618-7210
Edition Number
1
Number of Pages
IX, 252
Number of Illustrations and Tables
28 b/w illustrations, 47 illustrations in colour
Topics