Current Cancer Research

Targeted Therapy of Acute Myeloid Leukemia

Editors: Andreeff, Michael (Ed.)

  • Presents updated contemporary classification systems of myeloid leukemias, their genetic defects and the proteomic alterations characteristic of acute myeloid leukemia
  • Summarizes and interprets targeted in acute myeloid therapies, along with future therapeutics
  • Serves as a useful guideline to scientists, translational researchers and clinicians in the field
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eBook $189.00
price for USA (gross)
  • ISBN 978-1-4939-1393-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-1-4939-1392-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-1-4939-3989-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book provides an unprecedented overview of "Targeted Therapies" for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies round up this overview of the multi-dimensional therapeutic landscape in which leukemia specialists develop treatment strategies that are expected to make "leukemia history" in the near future.

Table of contents (44 chapters)

  • Genetics and Classification of Acute Myeloid Leukemia

    Walker, Alison R. (et al.)

    Pages 1-25

  • The Use of “Omics” to Guide the Selection of Targeted Therapy

    Kornblau, Steven M.

    Pages 27-43

  • Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML

    Reed, John C.

    Pages 47-65

  • Bcl-2 Family: Translational Aspects

    Bose, Prithviraj (et al.)

    Pages 67-94

  • IAP Family of Proteins as Therapeutic Targets for Acute Myeloid Leukemia

    Carter, Bing Z. (et al.)

    Pages 95-121

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4939-1393-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-1-4939-1392-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-1-4939-3989-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Targeted Therapy of Acute Myeloid Leukemia
Editors
  • Michael Andreeff
Series Title
Current Cancer Research
Copyright
2015
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-1-4939-1393-0
DOI
10.1007/978-1-4939-1393-0
Hardcover ISBN
978-1-4939-1392-3
Softcover ISBN
978-1-4939-3989-3
Series ISSN
2199-2584
Edition Number
1
Number of Pages
XIX, 826
Number of Illustrations and Tables
16 b/w illustrations, 46 illustrations in colour
Topics