Macrophages: Biology and Role in the Pathology of Diseases

Editors: Biswas, Subhra K., Mantovani, Alberto (Eds.)

  • Presents an updated view of the field which has undergone a significant evolution and new understanding in the last 10 years
  • Comprehensively covers new areas of monocyte/macrophage research like polarization states, monocyte subsets, their fate mapping and systems biology of macrophages
  • Provides a comprehensive section dedicated to the molecular mechanism of macrophage activation (signalling, transcription factors, post-transcriptional networks)
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eBook $189.00
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Hardcover $239.00
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  • ISBN 978-1-4939-1310-7
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Softcover $239.00
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  • ISBN 978-1-4939-5487-2
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About this book

Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells.

Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.

About the authors

Alberto Mantovani was born in Milan in 1948. He graduated (summa cum laude) in 1973 in Medicine at the University of Milan and in 1976 he specialized in Oncology at the University of Pavia. Since 2001 he is full Professor of General Pathology, School of Medicine, State University of Milan. Since October 2005 he is Scientific Director of Istituto Clinico Humanitas, Milan, Italy and President and founder of the Fondazione Humanitas per la Ricerca. In addition, the discovery that pro- and anti- inflammatory signals not only regulate the level of chemokine production but also the level of receptions offers a new level of understanding of how the system functions and possible targets for therapeutic interventions. Finally, his group has cloned the PTX3 (cDNA and genome, human and mouse), the first member of the long pentraxin family and defined his function in innate immunity and inflammation.

Dr. Biswas was born in Kolkata, India  in 1973. He completed his Ph.D. in Biotechnology (Cellular Immunology) in 2002, working on macrophage biology under Prof. A.  Sodhi at Banaras Hindu University, India. Thereafter, he was a postdoctoral visiting scientist at the Istituto di Ricerche Farmacologiche "Mario Negri", Milan (Italy) working in the group of Prof. A. Mantovani and A. Sica. During this period, he was awarded a fellowship of the Alfredo Leonardi and G. Pfeiffer Foundation (2003). His principal research contribution includes the first molecular characterization of tumor associated macrophages. In 2005, he joined the Bioinformatics Institute (A*STAR) in Singapore as Research Scientist (In-Charge) of the Cell Interaction group, before moving to Singapore Immunology Network (SIgN), A*STAR in 2007 to head the Human Innate Immunity lab. Dr. Biswas is also an adjunct associate professor in the Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore and Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Table of contents (29 chapters)

  • Blood Monocytes and Their Subsets in Health and Disease

    Ziegler-Heitbrock, Loems

    Pages 3-36

  • Polarized Activation of Macrophages

    Galdiero, Maria Rosaria (et al.)

    Pages 37-57

  • Alternative Activation of Macrophages: Concepts and Prospects

    Gordon, Siamon (et al.)

    Pages 59-76

  • Regulatory Macrophages and the Maintenance of Homeostasis

    Mosser, David M. (et al.)

    Pages 77-87

  • Phagocytosis

    Wolf, Andrea J. (et al.)

    Pages 91-109

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4939-1311-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-1-4939-1310-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-1-4939-5487-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Macrophages: Biology and Role in the Pathology of Diseases
Editors
  • Subhra K. Biswas
  • Alberto Mantovani
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-1311-4
DOI
10.1007/978-1-4939-1311-4
Hardcover ISBN
978-1-4939-1310-7
Softcover ISBN
978-1-4939-5487-2
Edition Number
1
Number of Pages
IX, 615
Number of Illustrations and Tables
77 b/w illustrations
Topics