Advances in Biochemistry in Health and Disease

Cardiac Energy Metabolism in Health and Disease

Editors: Lopaschuk, Ph.D., Gary D., Dhalla, Naranjan S. (Eds.)

  • Describes the research advances that have been made in understanding what controls cardiac energy metabolism at a molecular, transcriptional and physiological level
  • Describes how alterations in energy metabolism contribute to the development of heart disease
  • Written by leading researchers in the field
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eBook $149.00
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  • ISBN 978-1-4939-1227-8
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  • ISBN 978-1-4939-1226-1
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Softcover $189.00
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  • ISBN 978-1-4939-4879-6
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About this book

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease.

Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

About the authors

Dr. Gary Lopaschuk is a Distinguished Professor at the University of Alberta, Edmonton, Canada. His research focuses on the regulatory pathways involved in energy metabolism in the heart, particularly the integrated regulation of fatty acid oxidation and carbohydrate metabolism in the normal, diabetic and the reperfused ischemic heart. He has characterized a number of key enzymes important in the regulation of cardiac fatty acid oxidation and is exploring metabolic strategies to treat heart disease and obesity.

Dr. Naranjan Dhalla is a Distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged over the past 40 years in multidisciplinary research in ischemic heart disease, diabetic cardiomyopathy and heart failure as well as education for promoting scientific basis cardiology and training of professional manpower for combating heart disease.

Table of contents (18 chapters)

  • A Primer on Carbohydrate Metabolism in the Heart

    Taegtmeyer, Heinrich

    Pages 3-14

  • Lipoproteins: A Source of Cardiac Lipids

    Drosatos, Konstantinos (et al.)

    Pages 15-33

  • Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart

    Wan, Andrea (et al.)

    Pages 35-47

  • Control of Myocardial Fatty Acid Uptake

    Glatz, Jan F. C. (et al.)

    Pages 49-67

  • Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes

    Lopaschuk, Gary D.

    Pages 69-88

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4939-1227-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4939-1226-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-1-4939-4879-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cardiac Energy Metabolism in Health and Disease
Editors
  • Gary D. Lopaschuk, Ph.D.
  • Naranjan S. Dhalla
Series Title
Advances in Biochemistry in Health and Disease
Series Volume
11
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-1227-8
DOI
10.1007/978-1-4939-1227-8
Hardcover ISBN
978-1-4939-1226-1
Softcover ISBN
978-1-4939-4879-6
Edition Number
1
Number of Pages
XV, 295
Number of Illustrations and Tables
29 b/w illustrations, 25 illustrations in colour
Topics