Methods in Pharmacology and Toxicology

Genotoxicity and DNA Repair

A Practical Approach

Editors: Sierra, L. María, Gaivão, Isabel (Eds.)

  • Focuses on key assays in genotoxicity and DNA repair
  • Places special emphasis on the analysis of nanoparticles and nanomaterials
  • Features reproducible techniques and expert implementation advice
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eBook $109.00
price for USA (gross)
  • ISBN 978-1-4939-1068-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-4939-1067-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-1-4939-4829-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the “OECD guidelines for the testing of chemicals”, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.

Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study.

Table of contents (25 chapters)

  • Ames Test (Bacterial Reverse Mutation Test): Why, When, and How to Use

    Pillco, Araceli (et al.)

    Pages 3-22

  • The Ames II and Ames MPF Penta I Assay: A Liquid Microplate Format Modification of the Classic Ames Test

    Flückiger-Isler, Sini (et al.)

    Pages 23-41

  • Revised Procedure of the Bacterial Reverse Mutation Test for Genotoxic Evaluation of Nanoparticles

    Pagnout, Christophe (et al.)

    Pages 43-58

  • The Control of Hydrophobic Compound Exposure in In Vitro Tests for Genotoxicity

    Smith, Kilian E. C.

    Pages 59-72

  • The In Vitro Micronucleus Assay and FISH Analysis

    Migliore, Lucia (et al.)

    Pages 73-102

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-4939-1068-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-4939-1067-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-1-4939-4829-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Genotoxicity and DNA Repair
Book Subtitle
A Practical Approach
Editors
  • L. María Sierra
  • Isabel Gaivão
Series Title
Methods in Pharmacology and Toxicology
Copyright
2014
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-1068-7
DOI
10.1007/978-1-4939-1068-7
Hardcover ISBN
978-1-4939-1067-0
Softcover ISBN
978-1-4939-4829-1
Series ISSN
1557-2153
Edition Number
1
Number of Pages
XII, 483
Number of Illustrations and Tables
28 b/w illustrations, 42 illustrations in colour
Topics