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Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders

  • Book
  • © 2014

Overview

Editors:
  1. Maurizio Popoli

    1. Department of Pharmacological and Biomolecular Sciences, University of Milano, Milano, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. David Diamond

    1. Department of Psychology, University of South Florida, Tampa, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Gerard Sanacora

    1. Psychiatry Depression Research Program, Yale School of Medicine, New Haven, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Outlines recent evidence of glutamate synapse change caused by stress

  • Discusses how the effects of stress can trigger or precipitate neuropsychiatric disorders

  • Brings together leading researchers in the field

  • Includes supplementary material: sn.pub/extras

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. The Brain on Stress: The Good and the Bad

    • Bruce S. McEwen
    Pages 1-18

  3. Regulation of Excitatory Synapses by Stress Hormones

    • Marian Joëls, Harm Krugers, Henk Karst
    Pages 19-32

  4. Synaptic Stress, Changes in Glutamate Transmission and Circuitry, and Psychopathology

    • Laura Musazzi, Giulia Treccani, Carla Perego, Nicoletta Nava, Jens R Nyengaard, Maurizio Popoli
    Pages 33-52

  5. Dual Regulation of Glutamatergic Transmission and Cognition by Stress in Prefrontal Cortex

    • Yan Zhen
    Pages 53-69

  6. Role of Endocannabinoids in Regulating Glucocorticoid Effects on Memory for Emotionally Arousing Experiences

    • Piray Atsak, Benno Roozendaal, Patrizia Campolongo
    Pages 71-98

  7. Endocannabinoid Signaling and Synaptic Plasticity During Stress

    • J.Megan Gray, Haley A. Vecchiarelli, Matthew N. Hill
    Pages 99-124

  8. Stress-Induced Metaplasticity at GABA Synapses

    • Jaideep S. Bains
    Pages 125-136

  9. Stress Modulation of Synaptic Plasticity in the Hippocampus

    • Menahem Segal, Nicola Maggio
    Pages 137-150

  10. Neural-Cognitive Effects of Stress in the Hippocampus

    • Jeansok J. Kim, Blake A. Pellman, Eun Joo Kim
    Pages 151-165

  11. Evolutionary, Historical and Mechanistic Perspectives on How Stress Affects Memory and Hippocampal Synaptic Plasticity

    • George E. Farmer, Collin R. Park, Laura A. Bullard, David M. Diamond
    Pages 167-182

  12. Acute Stress Disrupts Short- and Long-Term Patterns of Synaptic Plasticity in Dorsal Hippocampus and Subiculum: Implications for Hippocampal Output and Behaviour

    • John G. Howland, Don A. Davies
    Pages 183-201

  13. Synaptic Mechanisms and Cognitive Computations Underlying Stress Effects on Cognitive Function

    • Gediminas Luksys, Carmen Sandi
    Pages 203-222

  14. Altered GABA function in Major Depression

    • Beverly French, Marianne L. Seney, Etienne Sibille
    Pages 223-244

  15. Pathology in Astroglia, Glutamate, and GABA in Major Depressive Disorder: Evidence from Studies of Human Postmortem Tissue

    • Grazyna Rajkowska
    Pages 245-264

  16. Evidence of Glutamatergic Dysfunction in the Pathophysiology of Schizophrenia

    • J.C. Hammond, D. Shan, J.H. Meador-Woodruff, R.E. McCullumsmith
    Pages 265-294

  17. Metabolic Stress and Neuropsychiatric Disorders

    • Claudia A. Grillo, Lawrence P. Reagan
    Pages 295-311

  18. Using Our Understanding of Stress-Related Effects on Glutamate Neurotransmission to Guide the Development of Novel Treatment Strategies

    • Carly Kiselycznyk, Gerard Sanacora
    Pages 313-341

  19. Back Matter

    Pages 343-355
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Keywords

About this book

Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.

Reviews

From the book reviews:

“This informative book, written and edited by an international array of well-known stress researchers, provides the latest information on the molecular mechanisms mediating stress in the pathogenesis of neuropsychiatric illnesses. … The target audience includes bench neuroscientists and clinicians who want to learn about the latest research on fundamental neuroendocrine stress mechanisms and stress-related diseases. … Each chapter ends with relevant and timely citations of the scientific literature.” (Michael Joel Schrift, Doody’s Book Reviews, January, 2015)

Editors and Affiliations

  • Department of Pharmacological and Biomolecular Sciences, University of Milano, Milano, Italy

    Maurizio Popoli

  • Department of Psychology, University of South Florida, Tampa, USA

    David Diamond

  • Psychiatry Depression Research Program, Yale School of Medicine, New Haven, USA

    Gerard Sanacora

Bibliographic Information

  • Book Title: Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders

  • Editors: Maurizio Popoli, David Diamond, Gerard Sanacora

  • DOI: https://doi.org/10.1007/978-1-4939-1056-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4939-1055-7Published: 28 July 2014

  • Softcover ISBN: 978-1-4939-4632-7Published: 03 September 2016

  • eBook ISBN: 978-1-4939-1056-4Published: 28 July 2014

  • Edition Number: 1

  • Number of Pages: XIV, 355

  • Number of Illustrations: 1 b/w illustrations, 48 illustrations in colour

  • Topics: Neurosciences, Neurology, Neurobiology

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