Molecular mechanisms and physiology of disease

Implications for Epigenetics and Health

Editors: Maulik, Nilanjana, Karagiannis, Tom (Eds.)

  • Includes chapters written by leading experts in the field
  • Examines major diseases (cardiovascular disease, respiratory disease, diabetes, cancer) from a molecular and physiological perspective
  • Includes section on epigenetics and translational therapies
see more benefits

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4939-0706-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-1-4939-0705-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-1-4939-4623-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Table of contents (18 chapters)

  • Epigenetics in Childhood Health and Disease

    Hussain, Naveed

    Pages 1-62

  • Role of Epigenetics in Neural Differentiation: Implications for Health and Disease

    Toraño, Estela G. (et al.)

    Pages 63-79

  • An Overview of Epigenetic Mechanisms in Health and Disease

    Westerland, Claire (et al.)

    Pages 81-112

  • Epigenetics: Role of Histone Proteases in Cellular Functions and Diseases

    Mandal, Papita (et al.)

    Pages 113-126

  • Anti-inflammatory Effects of Probiotics and Their Metabolites: Possible Role for Epigenetic Effects

    Türker, Nurşen (et al.)

    Pages 127-150

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4939-0706-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-1-4939-0705-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-1-4939-4623-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Molecular mechanisms and physiology of disease
Book Subtitle
Implications for Epigenetics and Health
Editors
  • Nilanjana Maulik
  • Tom Karagiannis
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4939-0706-9
DOI
10.1007/978-1-4939-0706-9
Hardcover ISBN
978-1-4939-0705-2
Softcover ISBN
978-1-4939-4623-5
Edition Number
1
Number of Pages
XIV, 505
Number of Illustrations and Tables
10 b/w illustrations, 33 illustrations in colour
Topics